Results 1 to 10 of about 1,026,270 (282)

Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS

open access: yesMolecular Therapy: Methods & Clinical Development, 2022
Adeno-associated viruses derived from human hematopoietic stem cells (AAVHSCs) are naturally occurring AAVs. Fifteen AAVHSCs have demonstrated broad biodistribution while displaying differences in transduction.
Laura J. Smith   +19 more
doaj   +1 more source

DNA read count calibration for single-molecule, long-read sequencing

open access: yesScientific Reports, 2022
There are many applications in which quantitative information about DNA mixtures with different molecular lengths is important. Gene therapy vectors are much longer than can be sequenced individually via short-read NGS.
Luis M. M. Soares   +6 more
doaj   +1 more source

New insights into the origin and relationships of blastoid echinoderms [PDF]

open access: yesActa Palaeontologica Polonica, 2021
“Pan-dichoporites” (new informal term) is proposed to unite Cambrian blastozoans, such as Cambrocrinus, Ridersia, and Sanducystis, glyptocystitoid and hemicosmitoid rhombiferans, coronates, blastoids, and Lysocystites.
Christopher R.C. Paul
doaj   +1 more source

LNA blockers for improved amplification selectivity

open access: yesScientific Reports, 2023
LNA-containing oligonucleotides bind DNA more tightly than standard DNA, so they can interact with targeted sequences and affect multiple processes. When a desired DNA is present at low concentrations relative to nearly identical undesired DNAs, LNAs can
Jaime Prout   +4 more
doaj   +1 more source

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH

open access: yesMolecular Therapy: Methods & Clinical Development, 2020
Phenylketonuria is an inborn error of metabolism caused by loss of function of the liver-expressed enzyme phenylalanine hydroxylase and is characterized by elevated systemic phenylalanine levels that are neurotoxic.
Seemin S. Ahmed   +14 more
doaj   +1 more source

Proteinortho6: pseudo-reciprocal best alignment heuristic for graph-based detection of (co-)orthologs

open access: yesFrontiers in Bioinformatics, 2023
Proteinortho is a widely used tool to predict (co)-orthologous groups of genes for any set of species. It finds application in comparative and functional genomics, phylogenomics, and evolutionary reconstructions.
Paul Klemm   +6 more
doaj   +1 more source

Chemical Composition, Antibacterial, Anti-Inflammatory, and Enzyme Inhibitory Activities of Essential Oil from Rhynchanthus beesianus Rhizome

open access: yesMolecules, 2020
Rhynchanthus beesianus W. W. Smith, an edible, medicinal, and ornamental plant, is mainly cultivated in China and Myanmar. The essential oil (EO) from R. beesianus rhizome has been used as an aromatic stomachic in China.
Xiaoge Zhao   +7 more
doaj   +1 more source

Infection and innate immune mechanism of goose astrovirus

open access: yesFrontiers in Microbiology, 2023
Goose astrovirus (GAstV, genus Avian Astrovirus, family Astrovirus) was first discovered in 2005, but was not considered as a pathogen of gosling gout until 2016.
Linhua Xu   +59 more
doaj   +1 more source

On the Embryonic Development of the Nasal Turbinals and Their Homology in Bats

open access: yesFrontiers in Cell and Developmental Biology, 2021
Multiple corrugated cartilaginous structures are formed within the mammalian nasal capsule, eventually developing into turbinals. Due to its complex and derived morphology, the homologies of the bat nasal turbinals have been highly disputed and uncertain.
Kai Ito   +8 more
doaj   +1 more source

Characterization of Gene Coding Fusion Protein of Newcastle Disease Virus Infected in Native Chicken in Surabaya

open access: yesJurnal Medik Veteriner, 2022
This study aimed to discover the homology of nucleotide sequence, homology percentage, and those relations phylogenetic of protein Fusion (F) gene coding of Newcastle disease in domestic chicken (Gallus gallus domesticus) in Surabaya using some ...
Maha Kirana   +3 more
doaj   +1 more source

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