Results 231 to 240 of about 1,026,270 (282)

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Assessment of the biochemical basis underlying the resistance against systemic amyloidosis. [PDF]

Sci Rep
Moderer T, Schnell AF, Scheurmann NJ, Schmidt M, Haupt C, Schwierz N, Fändrich M.   +6 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Improved genome assembly of Onygena corvina, a keratin-degrading fungus. [PDF]

BMC Res Notes
Pavale S, Eijsink VGH, La Rosa SL.
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Synteny plot quality control with SyntenyQC. [PDF]

Bioinformatics
Kirkwood TDJ, Connolly JA, Ang EL, Zhao H, Takano E, Breitling R.   +5 more
europepmc   +1 more source

Identification and genetic evolutionary analysis of goose circovirus in Shandong and neighboring provinces in China in 2024. [PDF]

Poult Sci
Yang X, Wang Y, Wu P, Zhu T, Zhang S, Yang X, Meng X, Jiang Z, Lu Y, Ning Z, Wu X, Song X, Jiang S, Wei L.   +13 more
europepmc   +1 more source

A novel prediction method for protein-DNA binding sites based on protein language model fusion features with SE-connection pyramidal network and ensemble learning. [PDF]

BMC Genomics
Zhang C, Jiang J, Zhao H, Song J.
europepmc   +1 more source

Benchmarking the PAM compatibility of Cas12a variants for high-throughput yeast genetic variant engineering. [PDF]

Appl Environ Microbiol
Xie W, Cai Z, Bao Z.
europepmc   +1 more source