Results 231 to 240 of about 1,015,655 (285)

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

A molecular survey of orthohantaviruses in rodents across the tri-border region of China, Russia, and North Korea. [PDF]

PLoS Negl Trop Dis
Peng Y, Gu Y, Li L, Zhang G, Liu Z, Liu N, Wang Z, Xu J, Wang Z.   +8 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Enhancing protein structure prediction: evaluating the role of amino acid physicochemical features in homology search. [PDF]

Brief Bioinform
Akbari Roknabadi S, Ahmadiyan H, Wong L, Koohi S.   +3 more
europepmc   +1 more source

Intestinal Colonization and Subsequent Nosocomial Infection with Carbapenem-Resistant Organisms in a PICU: Risk Factors and Molecular Homology Analysis. [PDF]

Infect Drug Resist
Yan G, Yang Y, Liu L, Yang W, He L, Wang Y, Zhou J, Chen W, Zhang Y, Zhang C, Fu P, Wang C, Lu G.   +12 more
europepmc   +1 more source

Topological data analysis and topological deep learning beyond persistent homology: a review. [PDF]

Artif Intell Rev
Su Z, Liu X, Hamdan LB, Maroulas V, Wu J, Carlsson G, Wei GW, Wei GW.   +7 more
europepmc   +1 more source

Genomic characterization of two duck-origin picornaviruses with seven putative 2A peptides. [PDF]

Front Vet Sci
Gao Y, Zhu T, Jiang Y, Tian F, Li Y, Liu W, Xu S, Tong Y, Qin Z, Hu F.   +9 more
europepmc   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective. [PDF]

Pharmacol Res Perspect
Fleming B, Guseinov AA, Tikhonova IG, Milligan G, Perry-Hauser NA.   +4 more
europepmc   +1 more source

Efficient multi-kilobase knock-ins in mice and cell lines using CRISPR/Cas9 and rAAV donors with unbiased whole-genome characterization by LOCK-seq. [PDF]

Nucleic Acids Res
Sentmanat MF, Wang ZT, Kouranova E, Peters ST, Chan WC, Lin J, Miao Y, White JM, Wallace M, Cui X.   +9 more
europepmc   +1 more source