Results 261 to 270 of about 660,490 (319)

Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals. [PDF]

Genome Biol Evol
Stephens TG, Kulczyk AW, Bhattacharya D.
europepmc   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Improved FTIR-based classification for food authentication using a topological ensemble framework. [PDF]

Curr Res Food Sci
Yu HC, Chen YK.
europepmc   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

Uncovering thousands of endosymbiont DNA transfer events within single cockroach genomes. [PDF]

Proc Natl Acad Sci U S A
Ewart KM, Adams MWD, Zhang Z, Baker L, Fujiwara K, Hayashi Y, Featherstone LA, Lu OL, Helbling JES, Moral M, Maekawa K, Rose H, Jex A, Ho SYW, Lo N.   +14 more
europepmc   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

Lessons learned from manual curation of thousands of gene models in the nematode Pristionchus pacificus. [PDF]

PLoS One
Rödelsperger C, Agyal N, Quiobe SP, Wu H, Röseler W, Ibarra-Morales D, Sommer RJ.   +6 more
europepmc   +1 more source

Flavonoids in Medicine and Food Homology Substances: Structure-Activity Relationship, Application Challenges, and Cutting-Edge Technological Breakthroughs. [PDF]

Foods
Wang X, Li Y, Zhao X, Fu D.
europepmc   +1 more source

CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons in <i>Leishmania mexicana</i>. [PDF]

Front Cell Infect Microbiol
McNiven C, Carnielli Trindade JB, Geoghegan V, Faria JRC, Mottram JC.   +4 more
europepmc   +1 more source