Results 151 to 160 of about 307,157 (265)

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

Genome-Wide Identification, Evolutionary Characterization, and Salt-Stress Expression Profiling of Antimicrobial Peptide Gene Families in the Xerophytic Recretohalophyte <i>Reaumuria soongarica</i>. [PDF]

Genes (Basel)
Wang Y, Chen S, Hussain A, Han X.
europepmc   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Enhanced Topical Treatment of Cutaneous Leishmaniasis Using Niosomal Gel of Tioxolone-Benzoxonium Chloride: In silico, in vitro, and in vivo Evaluation. [PDF]

Res Rep Trop Med
Hakimi Parizi M, Sharifi I, Molaakbari E, Salarkia E, Mostafavi M, Daie Parizi MH, Pardakhty A, Khamesipour A, Ghaffari D.   +8 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Systematic Profiling of ssODN Determinants Establishes Optimized LbCas12a-Mediated HDR for Precise Genome Editing in <i>Flammulina filiformis</i>. [PDF]

J Fungi (Basel)
Jia D, Liu X, Wang D, He X, Liang X, Peng W.   +5 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Genus-wide Homologous Recombination of Tail Fibers Maintains Tailocin Diversity in Pectobacterium. [PDF]

Genome Biol Evol
Pardeshi LA, Kupczok A, de Ridder D, Smit S, van der Lee TAJ.   +4 more
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Multidrug-resistant and virulent Streptococcus suis strains detected in clinically healthy pigs in Guangdong and Guangxi, China. [PDF]

Vet Res
Peng Z, Zhuang H, Liu R, Li F, Zhang S, Du P, Zheng H, Sun J, Quereda JJ, Wu Z.   +9 more
europepmc   +1 more source