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Protein structure homology modeling using SWISS-MODEL workspace
Nature Protocols, 2008Homology modeling aims to build three-dimensional protein structure models using experimentally determined structures of related family members as templates. SWISS-MODEL workspace is an integrated Web-based modeling expert system. For a given target protein, a library of experimental protein structures is searched to identify suitable templates. On the
Bordoli, L. +5 more
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Homology Modeling for Enzyme Design
2018Homology modeling is a very powerful tool in the absence of atomic structures for understanding the general fold of the enzyme, conserved residues, catalytic tunnel/pocket as well as substrate and product binding sites. This information is useful for structure-assisted enzyme design approach for the development of robust enzymes especially for ...
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Models, Homologies, and Simulacra
2011The research and academic work of the authors for the past decade or more has been centered on the arena known as “complexity” or “complex systems.” The study of complex systems has made major inroads in the mathematical world, but fewer inroads in the realm of social and organizational studies.
Hugo Letiche +2 more
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Homology Modeling with Low Sequence Identity
Methods, 1998The field of protein structure prediction is evolving rapidly and in the last few years a number of new methods have been developed and evaluated. However, comparative modeling, or modeling by homology, is still the method of choice when the unknown protein shares any significant sequence similarity with a protein of known structure.
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3D Homology Model of Sigma1 Receptor
2017This chapter presents the three-dimensional (3D) model of the Sigma1 receptor protein as obtained from homology modeling techniques. We show the applicability of this structure to docking-based virtual screening and discuss combined in silico/in vitro mutagenesis studies performed to validate the structural features of the Sigma1 receptor model and to ...
LAURINI, ERIK +3 more
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Phylogenetics and homology modeling
2008Phylogenetics uses nucleotide and/or amino acid sequences to construct evolutionary trees and reconstruct the sequences (or other characteristics) of ancestral organisms. Proteins function almost entirely in their folded form, but phylogenetic work typically does not directly consider the structures into which protein sequences fold.
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Mechanisms and principles of homology search during recombination
Nature Reviews Molecular Cell Biology, 2014Jörg Renkawitz, Stefan Jentsch
exaly