Results 111 to 120 of about 80,852 (330)

Excess of homozygosity for different microsatellites.

, 2013
Excess of homozygosity for different microsatellites.
John A Sved (435992), Emilie C. Cameron (435993), A. Stuart Gilchrist (435994)   +2 more
core   +1 more source

Fitness and the level of homozygosity in a social insect [PDF]

, 2009
To date very few studies have addressed the effects of inbreeding in social Hymenoptera, perhaps because the costs of inbreeding are generally considered marginal owing to male haploidy whereby recessive deleterious alleles are strongly exposed to ...
Keller, Laurent, Haag-Liautard, Cathy, Keller, L., Haag-Liautard, C., Vitikainen, E., Sundström, L.   +5 more
core   +1 more source

Frequency of Favorable Alleles for Meat Quality, Litter Size, Adaptation, and Growth Traits in Closed Nucleus Population of Philippine Native Swine (Sus philippensis var. markaduke)

Cluj Veterinary Journal
The Philippine native swine (PNS) are heritage domestic animal genetic resources for food security and geo-cultural uses.  Among the PNS, the markaduke is known for the "best lechon" (roast whole pork) and comminuted pork products, moderate litter size (
Arnolfo Monleon
doaj   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Excess of homozygosity in the major histocompatibility complex in schizophrenia [PDF]

, 2014
Genome-wide association studies (GWAS) in schizophrenia have focused on additive allelic effects to identify disease risk loci. In order to examine potential recessive effects, we applied a novel approach to identify regions of excess homozygosity in an ...
Malhotra, Anil, Ikeda, M., Pe\u27er, I., Guha, S., Mukherjee, S., Darvasi, A., Lencz, T., Iwata, N.   +7 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia

Frontiers in Genetics, 2019
Recent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry.
Sergey A. Kornilov, Sergey A. Kornilov, Mei Tan, Abdullah Aljughaiman, Oxana Yu Naumova, Oxana Yu Naumova, Elena L. Grigorenko, Elena L. Grigorenko, Elena L. Grigorenko, Elena L. Grigorenko   +9 more
doaj   +1 more source

Molecular Genetic Analysis of Pakistani Families With Autosomal Recessive Congenital Cataracts by Homozygosity Screening

Investigative Ophthalmology and Visual Science, 2017
Purpose To identify the genetic origins of autosomal recessive congenital cataracts (arCC) in the Pakistani population. Methods Based on the hypothesis that most arCC patients in consanguineous families in the Punjab areas of Pakistan should be ...
Jianjun Chen, Qiwei Wang, Patricia E. Cabrera, Z. Zhong, Wenmin Sun, Xiao-Dong Jiao, Ya-Bin Chen, Gowthaman Govindarajan, M. Naeem, Shaheen N. Khan, M. H. Ali, M. Z. Assir, Fawad Ur Rahman, Z. Qazi, S. Riazuddin, J. Akram, S. Riazuddin, J. Hejtmancik   +17 more
semanticscholar   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Homozygosity in any HLA locus is a risk factor for specific antibody production: the taboo concept 2.0

Frontiers in Immunology
ObjectiveIn a cooperative study of the University Hospital Leipzig, University of Leipzig, and the Charité Berlin on kidney transplant patients, we analysed the occurrence of HLA-specific antibodies with respect to the HLA setup of the patients. We aimed
Henry Loeffler-Wirth, Claudia Lehmann, Nils Lachmann, Ilias Doxiadis   +3 more
doaj   +1 more source