Results 81 to 90 of about 80,852 (330)

Homozygosity and ROH regions.

, 2012
Mean homozygosity of SNPs in a sliding window (200-kb window at 100-kb steps) was plotted versus the location on 2L (A), 2R (B), 3L (C), 3R (D) and X (E) chromosomes.
Atsushi Toyoda (24202), Asao Fujiyama (140709), Jun Zhou (6477), Minako Izutsu (178786), Yuzo Sugiyama (178791), Kiyokazu Agata (30383), Tomoyuki Aizu (178795), Osamu Nishimura (106269), Naoyuki Fuse (178805)   +8 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Ile/Ile homozygosity at codon 655 of HER2 in schwannoma

, 2013
Purpose: This study aimed to determine the genetic role of HER2, one of the epidermal growth factor receptor (EGFR) family, in schwannoma. The latter is a neogrowth of myelin-producing Schwann cells in peripheral nerves, inducible by N-nitrosoethylurea ...
Vin-Chi Wang; Jhy-Wei Li; Jeng-Hung Suen; Chuang, Tzu-Chao; Ming-Ching Kao
core   +1 more source

KinSNP software for homozygosity mapping of disease genes using SNP microarrays

Human Genomics, 2010
Consanguineous families affected with a recessive genetic disease caused by homozygotisation of a mutation offer a unique advantage for positional cloning of rare diseases.
Amir El-Ad, Bartal Ofer, Morad Efrat, Nagar Tal, Sheynin Jony, Parvari Ruti, Chalifa-Caspi Vered   +6 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Heterotic potential for Physalis peruviana fruit traits in hybrid combinations [PDF]

Revista Brasileira de Fruticultura
: The breeding of Physalis peruviana is incipient in Brazil and is shown to be the most promising alternative for the development of productive genotypes with fruit quality.
Nicole Trevisani, Rita Carolina de Melo, Paulo Henrique Cerutti, Patrícia Maria Oliveira Pierre, Jefferson Luís Meirelles Coimbra, Altamir Frederico Guidolin   +5 more
doaj   +1 more source

Management of Genetic Diversity in the Era of Genomics

Frontiers in Genetics, 2020
Management of genetic diversity aims to (i) maintain heterozygosity, which ameliorates inbreeding depression and loss of genetic variation at loci that may become of importance in the future; and (ii) avoid genetic drift, which prevents deleterious ...
Theo H. E. Meuwissen, Anna K. Sonesson, Gebreyohans Gebregiwergis, John A. Woolliams   +3 more
doaj   +1 more source

Genomic Patterns of Homozygosity in Chinese Local Cattle

Scientific Reports, 2019
Genome-wide single nucleotide polymorphism (SNP) arrays can be used to explore homozygosity segments, where two haplotypes inherited from the parents are identical. In this study, we identified a total of 27,358 runs of homozygosity (ROH) with an average
Lingyang Xu, Guoyao Zhao, Liu Yang, Bo Zhu, Yan Chen, Lu-Pei Zhang, Xue Gao, Huijiang Gao, George E. Liu, Jun-Ya Li   +9 more
semanticscholar   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Low Heterozygosity and Historical Bottleneck Effect Depicted From the Genome Assembly of the Indus River Dolphin (Platanista minor)

Ecology and Evolution
The Indus River dolphin (Platanista minor) is a highly endangered freshwater dolphin endemic to the Indus River system of the Indian subcontinent. We reported a de novo assembly and characterization of the draft genome of the Indus River dolphin by using
Aamir Ibrahim, Simin Chai, Cuijuan Zhong, Kang Jieqiong, Ahsaan Ali, Sajjad Hussain, Hassan Ali, Tanveer Hussain, Umer Waqas, Guang Yang   +9 more
doaj   +1 more source