Results 191 to 200 of about 73,318 (285)

APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract BACKGROUND Apolipoprotein E (APOE) alleles are well‐established genetic risk factors for Alzheimer's disease (AD), but their effects on AD biomarkers (amyloid beta [Aβ]42/40, phosphorylated tau [p‐tau]181, neurofilament light chain [NfL], and glial fibrillary acidic protein [GFAP]) may vary across populations due to ancestry‐, age‐, and sex ...
Caitlin Cheung, Natasha Z. Anita, Paola Filigrana, Myriam Fornage, Kevin A. Gonzalez, Linda C. Gallo, Carmen R. Isasi, Robert C. Kaplan, Xihao Li, Freddie Márquez, Humberto Parada Jr., Krista M. Perreira, Alberto R. Ramos, Tatjana Rundek, Wassim Tarraf, Fernando D. Testai, Charles DeCarli, Hector M. González, Tamar Sofer   +18 more
wiley   +1 more source

Decreased Aryl Hydrocarbon Receptor Gene Expression and Polymorphic Variants Association with Increase COPD Risk. [PDF]

Int J Chron Obstruct Pulmon Dis
Sadr M, Asgari A, Assadiasl S, Mojtahedi H, Abdollahi A, Nicknam MH, Edalatifard M, Soleimanifar N.   +7 more
europepmc   +1 more source

Treatment of Familial Hypercholesterolemia Homozygote

The Journal of Japan Atherosclerosis Society, 1982
Rikurou HAYASHI, Hideki KOH, Yasuko NISHIOHEDA, Makoto SATANI, Seiki NAMBU, Masao IKEDA, Mamoru TAKEUCHI, Tetsurou KAMIYA, Taku YAMAMURA, Akira YAMAMOTO   +9 more
openaire   +2 more sources

Effectiveness, safety, and biomarker dynamics of lecanemab in Chinese Alzheimer's disease population: a multicenter real‐world study

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
ABSTRACT BACKGROUND Lecanemab, an anti–amyloid beta (Aβ) protofibril antibody, was introduced in China in 2024, but its real‐world performance remains unknown. METHODS In this prospective, multicenter study across 21 sites, 261 Alzheimer's disease patients (mild cognitive impairment to moderate dementia) received biweekly lecanemab (10 mg/kg).
Wang Liao, Qun Yu, Bin Chen, Hualin Chen, Liangyu Zou, Haiqun Xie, Haobo Chen, Chenyang Wang, Yang Li, Xiaoya Gao, Hongbo Guo, Ying Yang, Ziyu She, Qinggan Zeng, Zengqiang Zhang, Guihua Li, Shujun Feng, Han Lin, Jipeng Ouyang, Junyan Liang, Wenling Ao, Qiong Zeng, Zhou Liu, Hanyu Weng, Hongqiang Huang, Feiqi Zhu, Runni Liu, Yingte Wang, Dapeng Yu, Xue Li, Yingren Mai, Shengnan Jiang, Yu Tu, Zhiming Li, Jun Liu, for the Alzheimer's Disease Neuroimaging Initiative   +35 more
wiley   +1 more source

Population frequencies of thiopurine-related pharmacogenes in healthy individuals from Kosovo. [PDF]

Hum Genome Var
Pasha F, Urbančič D, Gosheva G, Zhubi B, Maliqi Qormemeti S, Krasniqi S, Mlinarič-Raščan I.   +6 more
europepmc   +1 more source

The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factors converge on neuromodulatory subcortical systems to confer AD risk or resilience.
Alfie Wearn, Kate M. Onuska, Taylor W. Schmitz, Gary R. Turner, R. Nathan Spreng   +4 more
wiley   +1 more source

Evaluation of the Association of TNF-α rs361525 Gene Polymorphism in Bangladeshi Patients With Breast and Cervical Cancer: A Case-Control Study and Meta-Analysis. [PDF]

Health Sci Rep
Dewan SMR, Proma AY, Khan SA, Meem SS, Alam MT, Barek MA, Urmi TJ, Sazzad Hossain ATM, Bhuiyan MA, Islam MS, Shahriar M.   +10 more
europepmc   +1 more source

Television and computer use and dementia risk in older adults with limited leisure or social activities: A prospective cohort study

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Associations between television/computer use and dementia in socially inactive older adults remain unclear, and optimal limits are unknown. METHODS We followed 89,671 dementia‐free, socially inactive adults aged ≥55 from UK Biobank for a mean of 12.2 years. Adjusted Cox models assessed associations with incident all‐cause dementia
Jiaying Li, Hongliang Xue, Yue Leng, Quincy M. Samus, Milap Nowrangi, Sarah L. Szanton, Qian‐Li Xue, Juxnin Li   +7 more
wiley   +1 more source

Interindividual variability in the prevalence of OPRM1 and CYP2B6 gene variations may identify drug-susceptible populations [PDF]

, 2011
Bunten, Hannah, Liang, Wei-Jun, Osselton, David M., Pounder, Derrick   +3 more
core  

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis—Application in a Real‐World Setting

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 2, March 2026.
ABSTRACT Introduction Genetic factors are thought to play an important role in antipsychotic‐induced weight gain (AIWG). Polygenic risk scores (PRS) could provide a measure of genetic predisposition to antipsychotic drug induced weight gain (AIWG).We conducted a study to examine how a PRS, generated using SNPs, identified from a recent meta‐analysis ...
Adrian Heald, Yasitha Illangasekera, Camila Marcelino Loureiro, Mark Shakespeare, Adam Jameson, Adrian Phillipson, Gavin P. Reynolds, Caroline Dalton   +7 more
wiley   +1 more source