Results 121 to 130 of about 444,809 (263)

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Medullary thyroid carcinoma exclusively associated with a homozygous RET V778I pathogenic variant: a case report with review of literature

Endocrine Journal
Medullary thyroid carcinoma (MTC) can occur sporadically or as a hereditary disease. The latter often presents with a multiple endocrine neoplasia type 2 (MEN2) phenotype and is caused by germline-activating pathogenic variants in the RET proto-oncogene,
Minoru Kihara, Akira Miyauchi, Takashi Akamizu   +2 more
doaj   +1 more source

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

, 2012
Subclones homozygous for JAK2V617F are more common in polycythemia vera (PV) than essential thrombocythemia (ET), but their prevalence and significance remain unclear.
Chen, Edwin, Lippert, Eric, Green, Anthony R., Harrison, C., Silber, Yvonne, Döhner, Konstanze, Harrison, Claire N, Campbell, P.J., McMullin, Mary F, Vannucchi, A.M., Guglielmelli, P., Pagano, F., Stegelmann, F., Stegelmann, Frank, Campbell, Peter J, Harrison, Claire N., Boiron, J.M., Chen, E., Pagano, Francesca, Green, A.R., Reilly, J.T., Guglielmelli, Paola, Reilly, John T, Bijou, Fontanet, Bijou, F., Lippert, E., McMullin, Mary F., Bellosillo, Beatriz, Reilly, John T., Godfrey, Anna L, Ortmann, Christina A., Campbell, Peter J., Godfrey, A.L., Belosillo, B., McMullin, M.F., Boiron, Jean-Michel, Ortmann, C.A., Silber, Y., Besses, C., Ortmann, Christina A, Vannucchi, Alessandro M, Döhner, Konstanze, Doehner, K., Godfrey, Anna L., Besses, Carlos, Vannucchi, Alessandro M., Green, Anthony R   +46 more
core   +1 more source

Herbivory‐Induced Stomatal Opening Triggers the Dispersal of an Invasive Insect Herbivore

Advanced Science, EarlyView.
The invasive leafminer Phthorimaea absoluta uniquely manipulates plant defenses by inducing stomatal opening in tomato. This response, mediated by the stomatal regulator IQM1, enhances the release of the repellent volatile benzaldehyde. This volatile triggers the dispersal of adult moths, facilitates colonization of new hosts, and leads to rapid ...
Limin Chen, Xiaowei Li, Yaru Wang, Farman Ullah, Shuxing Zhou, Lemeng Dong, Weizhong He, Harro J. Bouwmeester, Youming Hou, Ian T. Baldwin, Yaobin Lu   +10 more
wiley   +1 more source

THE EVALUATION OF HEALTH STATUS OF FAMILIAL MEDITERRANEAN FEVER PATIENTS WITH HOMOZYGOUS M694V MUTATION

Rheumatology Quarterly
Aim: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder characterized by recurrent episodes of fever, serositis, and systemic inflammation.
Ayşegül Çakar, Lale Saka Baraz, Demet Yalçın Kehribar, Metin Özgen   +3 more
doaj   +1 more source

Isolation of UTF1 homozygous mutant ESCs from blastocysts.

, 2013
(A) Western blot analyses of pluripotency marker proteins in ESCs generated by outgrowth of UTF1 homozygous and heterozygous mutant blastocysts. (B) Comparison of the differentiation propensity between UTF1 homozygous and heterozygous mutant ESCs.
Masatsugu Ema (200616), Akihiko Okuda (431640), Yoko Satta (126775), Hidemasa Kato (431639), Masayoshi Kamon (431635), Yoko Kuroki (88657), Ryuichi Ono (25601), Satoru Takahashi (32871), Toshiyuki Yamagishi (431633), Yoko Nabeshima (431638), Janine E. Deakin (51244), Miyuki Katano (30033), Tomoaki Hishida (431634), Masataka Hirasaki (431637), Jennifer A. Marshall Graves (14416), Yukako Katsura (126771), Yo-ichi Nabeshima (267668), Fumitoshi Ishino (25608), Masazumi Nishimoto (431632), Ayumu Suzuki (431636)   +19 more
core   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source

Comprehensive BRCA1/2 mutation landscape in prostate cancer in the UAE and Arab population

Frontiers in Cell and Developmental Biology
BackgroundProstate cancer (PCa) is the most common malignancy among men in the United Arab Emirates (UAE) and is often diagnosed at advanced stages with aggressive features. Germline mutations in DNA-repair genes, especially BRCA1 and BRCA2, increase PCa
Zainab M. Al Shareef, Zainab M. Al Shareef, Rula M. Al-Shahrabi, Poorna Manasa Bhamidimarri, Burcu Yener, Amal Bouzid, Alaa Mohamed Hamad, Shirin Murad, Ahmed Elbarkouky, Fatemeh Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Riyad Bendardaf, Riyad Bendardaf, Riyad Bendardaf, Rifat A. Hamoudi, Rifat A. Hamoudi, Rifat A. Hamoudi, Mahmood Y. Hachim   +17 more
doaj   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

A homozygous female hemophilia A

, 2012
Background: Hemophilia A (HA), being an X-linked recessive disorder, females are rarely affected, although they can be carriers. Aims: To study the mutation in F8 gene in an extended family with a homozygous female HA.
Nair, Preethi S., Ghosh, Kanjaksha, Shetty, S.   +2 more
core   +2 more sources