Results 151 to 160 of about 444,809 (263)

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Gestational trophoblastic neoplasms in homozygous twins

, 1982
The occurrence of gestational trophoblastic disease in homozygous twins is described. The correlation between this finding and current genetic hypotheses on the pathogenesis of hydatidiform mole is ...
C. Mangioni, M. Fasoli, C. La Vecchia, S. Franceschi   +3 more
core   +1 more source

Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations. [PDF]

PLoS Biol
Lin Y, van der Bijl W, Mank JE.
europepmc   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Identification of a Novel homozygous Splice-Site Deletion in <i>KCTD7</i> Gene Associated with Progressive Myoclonic Epilepsy. [PDF]

Pak J Med Sci
Alharazy S, Pushparaj PN, Jelani R, Bibi F, Muthaffar OY, Naseer MI.   +5 more
europepmc   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

Advanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran, Fangchi Shao, Gregory Datto, Tathansh Joshi, Elizabeth Chatt, Yashar Bashirzadeh, Dan Stessman, Lai Wei, Kuangwen Hsieh, Hena Guo, Tza‐Huei Wang   +10 more
wiley   +1 more source

Expanding the Progeroid Laminopathy Spectrum: Clinical Variability and Later-Onset Phenotype in Homozygous LMNA c.1579C>T (p.Arg527Cys) Associated Mandibuloacral Dysplasia. [PDF]

Case Rep Genet
Arany ES, Zocche D, Cobben J.
europepmc   +1 more source

Identification of a Novel Homozygous Mutation in MTMR2 Gene Causes Very Rare Charcot–Marie–Tooth Disease Type 4B1

The Application of Clinical Genetics
Nan Du,1 Xiaolei Wang,1 Zhaohui Wang,2 Hongwei Liu,1 Hui Liu,1 Hongfang Duan,1 Shaozhi Zhao,1 Santasree Banerjee,3 Xinwen Zhang1 1Department of Medical Genetics, Xi’an People’s Hospital (Xi’an Fourth Hospital), Xi’an, Shaanxi, 710004, People’s Republic ...
Du N, Wang X, Wang Z, Liu H, Liu H, Duan H, Zhao S, Banerjee S, Zhang X   +8 more
doaj  

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Diazoxide-Responsive Congenital Hyperinsulinism in a Preterm Infant With Homozygous <i>ABCC8</i> Mutation: A Case Report. [PDF]

Case Rep Endocrinol
Kansakar P, Gurung G, Bhandari S, Shrestha K, G C B, Thapa S, Acharya R.   +6 more
europepmc   +1 more source