Results 61 to 70 of about 444,809 (263)
Cutaneous Xanthomas in a Young Boy – Markers of Homozygous Familial Hypercholesterolemia
Indian Pediatrics Case ReportsBackground: Homozygous familial hypercholesterolemia (HoFH) is a rare and potentially devastating, genetic cause of elevated lipid levels in children. Clinical Description: A 4-year-old boy presented with small, painless, nondischarging, nonpruritic, and
Gourav Kumar Goyal +3 more
doaj +1 more source
Julius-Kühn-Archiv, 2014 In field experiments the control of blackgrass (Alopecurus myosuroides, Huds.) in oilseed rape using clethodim (Select EC 240) and cycloxydim (Focus Ultra) with and without subsequent treatments with propyzamide (Kerb FLO) was tested at 6 locations in ...
Wagner, Jean +4 more
doaj +1 more source
, 2023 : We report a newborn patient with trichothiodystrophy-3 (TTD3) caused by a novel homozygous variant in the GTF2H5 gene. His severe phenotype included congenital ichthyosis, complex posterior cranial fossa anomaly, life-threatening infections, bilateral ...
Ugo Sorrentino +17 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli +10 more
wiley +1 more source
Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation [PDF]
, 2009 Background: Wnt signaling controls the balance between stem cell proliferation and differentiation and body patterning throughout development. Previous data demonstrated that non-canonical Wnts (Wnt5a, Wnt11) increased cardiac gene expression of ...
Leitges, Michael +11 more
core +2 more sources
Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle
Advanced Functional Materials, EarlyView.This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang +18 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu +5 more
wiley +1 more source
Advanced Materials, EarlyView.A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian +7 more
wiley +1 more source
Heterozygous/Homozygous domeMESOGFP.
Heterozygous cross of UAS TraF; + x domeMESOGFP and homozygous cross of UAS TraF;domeMESOGFP x domeMESOGFP, separated by sex. (A) Raw total nuclei count of heterozygous females(n = 17) and homozygous females(n = 16) are shown to have no significant ...
Alexandra Dvoskin (24376135) +6 more
core +1 more source
A neonate with homozygous protein C deficiency with a homozygous arg178trp mutation
, 2008 PubMedID: 18799939Homozygous protein C deficiency affects approximately 1/400,000 to 1/1,000,000 live births. Homozygous protein C deficiency is associated with catastrophic and fatal purpura fulminans-like or thrombotic complications and disseminated ...
Ozcan K. +6 more
core +1 more source