Results 121 to 130 of about 1,550,928 (266)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

Gastrointestinal Problems in Chinese Children with Autism Spectrum Disorder

open access: yesNeuropsychiatric Disease and Treatment, 2020
Kelly YC Lai,1 Patrick WL Leung,2 Se Fong Hung,1 Caroline KS Shea,3 Flora Mo,3 Kiti KI Che,3 Chun-Yu Tse,2 Fanny LF Lau,1 Suk Ling Ma,1 Justin CY Wu,4 Suzanne So,2 Mark R Dadds5 1Department of Psychiatry, Chinese University of Hong Kong, Shatin, Hong ...
Lai KYC   +11 more
doaj  

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

open access: yesAdvanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao   +9 more
wiley   +1 more source

Hong Kong as a Test Case for World Literature

open access: yesSanglap: Journal of Literary and Cultural Inquiry, 2017
This article posits Hong Kong as a test case for several theoretical perspectives currently developed in the rising field of world literature. Focusing on three main areas—namely, Hong Kong’s semi-peripheral neocoloniality, its language politics, and the
Michael Tsang
doaj  

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

open access: yesAdvanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li   +6 more
wiley   +1 more source

Effectiveness of a life story work program on older adults with intellectual disabilities

open access: yesClinical Interventions in Aging, 2014
Xue Bai,1,2 Daniel WH Ho,2 Karen Fung,3 Lily Tang,3 Moon He,3 Kim Wan Young,4 Florence Ho,2 Timothy Kwok2,5 1Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; 2Jockey Club Centre for Positive ...
Bai X   +7 more
doaj  

Human Trafficking and Judicial 'Divination' in Hong Kong

open access: yes, 2018
The Court of Appeal’s (CA) recent ruling in ZN v Secretary for Justice on human trafficking is problematic for three reasons. First, it read too much into the People’s Republic of China’s choice not to apply the Palermo Protocol to Hong Kong. Second, the
Lee, HLK, Yap, PJ
core  

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

open access: yesAdvanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu   +8 more
wiley   +1 more source

Kong Yunming v Director of Social Welfare: Implications for Law and Policy on Social Welfare

open access: yes, 2014
Kong Yunming v Director of Social Welfare is a landmark victory for the protection of constitutional social welfare right in Hong Kong. In this unanimous decision of the Court of Final Appeal, the seven-year residence requirement for Comprehensive ...
Kong, K, Kong, KY
core  

Speech therapy and general practice in Hong Kong [PDF]

open access: yes, 1997
Speech therapy services in Hong Kong have changed dramatically in the past two decades. Further development is urgently required in three main areas; norms of speech and language development in Cantonese, descriptions of disordered communication in ...
Yiu, E, Stokes, SF
core  

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