Results 31 to 40 of about 34,165 (268)

State Size and Democratization in Hybrid Regimes: The Chinese Island Cities of Macau and Hong Kong

Island Studies Journal, 2017
The effect of state size on level of democratization has been a topic of interest to political scientists. However, studies have largely focused on democratic regimes, leaving unexplored the implications of state size for the regime persistence of hybrid
Ying-ho Kwong, Mathew Y.H. Wong
doaj   +2 more sources

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

Cancer Biology & Medicine, 2020
Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation ...
Wu Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Denise So Bik Chan, Simon Wing Fai Mok, Joyce Jia Ying Gao, Rebecca Ka Yan Ho, Xu Liang, Jia Hao Li, Ming Tsung Lee, Weng Li Yoon, Michael P Smolinski, Johnson Yiu Nam Lau, Christopher Wai Kei Lam, Manson Fok   +14 more
doaj   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Housing Price Gradient Between Macau and Hong Kong [PDF]

, 2007
This paper applies a two-workplace residential location choice model to study the housing price gradient changes between Macau and Hong Kong. The classical land market model assumes a one-workplace scenario.
Yiu, CY
core  

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

International development and safeguard mechanism of the Guangdong-Hong Kong-Macao Greater Bay Area (Guangdong) Hub of “Channel Computing Resources from the East to the West”

大数据, 2023
The digital economy has become a focal point for national economic development, and Guangdong's collaboration with Hong Kong and Macau plays an important role in exploring digitalization.The computing power center serves as the cornerstone of digital ...
Yang DU, Xiaofang CAI, Biao LI
doaj  

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

Effects of Facets of Mindfulness on College Adjustment Among First-Year Chinese College Students: The Mediating Role of Resilience

Psychology Research and Behavior Management, 2021
Yanbo Dong,1 Le Dang,1– 3 Shenglan Li,4– 6 Xue Yang7,8 1Faculty of Teacher Education, Pingdingshan University, Pingdingshan, Henan, 467000, People’s Republic of China; 2Department of Psychology, Faculty of Social Sciences, University of Macau, Macau ...
Dong Y, Dang L, Li S, Yang X
doaj  

Prevalence of internet addiction disorder in Chinese university students: A comprehensive meta-analysis of observational studies [PDF]

, 2018
Background and aims: Internet addiction disorder (IAD) is common in university students. A number of studies have examined the prevalence of IAD in Chinese university students, but the results have been inconsistent.
Chai, Jing-Xin, Li, Lin, Li, Lu, Lu, Li, Mei, Song-Li, Ng, Chee H, Ungvari, Gabor S, Wang, Di, Xiang, Yu-Tao, Xu, Dan-Dan, Zhang, Ling   +10 more
core   +3 more sources