Results 191 to 200 of about 1,478,706 (306)

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Computational Modeling of Cellular Influence Delineates Functionally Relevant and Distinct Cellular Neighborhoods in Primary and Metastatic Pancreatic Ductal Adenocarcinoma. [PDF]

Cancer Immunol Res
Cho Y, Lee JW, Shin SM, Hernandez AG, Yuan X, Schneider J, Hooper JE, Wood LD, Jaffee EM, Deshpande A, Ho WJ.   +10 more
europepmc   +1 more source

Development and Retrospective Application of Novel Outcome Measure: Sturge–Weber Syndrome Acute Crisis (SWAC) Index

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Sturge–Weber syndrome (SWS) symptoms frequently overlap in neurological acute crises (ACs) presenting with seizures, stroke‐like episodes (SLE), and headaches. Recent efforts to develop a prospective drug trial highlighted the need for a new outcome measure capable of quantifying these symptoms during an SWS AC.
Kieran D. McKenney, Luther G. Kalb, Adrienne M. Hammill, Anne M. Comi   +3 more
wiley   +1 more source

Recurrent and new primary cancer risk in adult patients with idiopathic inflammatory myositis and a history of malignancy. [PDF]

Clin Exp Rheumatol
Wang X, Albayda J, Paik JJ, Tiniakou E, Adler BL, Mammen AL, Casciola-Rosen L, Christopher-Stine L, Mecoli CA.   +8 more
europepmc   +1 more source

Cardiorenal Outcomes of Dapagliflozin vs. Empagliflozin in Advanced Chronic Kidney Disease and Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Target trial emulation of a multi‐institutional electronic health record network showed comparable cardiorenal effectiveness and safety of dapagliflozin versus empagliflozin in adults with type 2 diabetes and advanced‐stage chronic kidney disease.
Shih‐Hsuan Lin, Jia‐Jin Chen, Ching‐Chung Hsiao, Yu‐Wei Fang, Meng‐Ting Chen, Ming‐Hsien Tsai, Huang‐Yu Yang   +6 more
wiley   +1 more source

Lethal toxin-equipped effector cells for the potential treatment of cancer. [PDF]

Proc Natl Acad Sci U S A
Pearlman AH, Mog BJ, Hwang MS, Rincon-Torroella J, DiNapoli SR, Paul S, Douglass J, Hsiue EH, Glavaris SA, Pardoll DM, Papadopoulos N, Kinzler KW, Bettegowda C, Zhou S, Vogelstein B, Konig MF.   +15 more
europepmc   +1 more source

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, EarlyView.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal. [PDF]

Bioinformatics
Mitchell JT, Stapleton O, Krishnan K, Nagaraj S, Lvovs D, Cherry C, Poissonnier A, Horton W, Adey A, Rao V, Huff A, Zimmerman JW, Kagohara LT, Zaidi N, Coussens LM, Jaffee EM, Elisseeff JH, Fertig EJ.   +17 more
europepmc   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Las celebraciones populares como construcción y reafirmación identitaria.

Telondefondo : Revista de Teoría y Crítica Teatral, 2009
Perla Zayas de Lima
doaj   +1 more source