Results 41 to 50 of about 571,820 (316)
A smooth horizon without a smooth horizon
Journal of High Energy PhysicsAbstract Recent observations on type III algebras in AdS/CFT raise the possibility that smoothness of the black hole horizon is an emergent feature of the large-N limit. In this paper, we present a bulk model for the finite-N mechanism underlying this transition.
Burman, V, Das, S, Krishnan, C
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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L’idée d’une science littéraire et la phénoménologie de la lecture
Methodos, 2020 This article aims at accounting for the project of a Husserl-inspired foundation of a science of literature. This foundation leads firstly to the task of describing the eidetically definite correlation in which the sense “literary work” happens to be ...
Aurélien Djian
doaj
Archaeoastronomical object on Tuzluk Mount in the Elbrus region (Northern Caucasus) [PDF]
Archaeoastronomy and Ancient Technologies, 2019 The article presents the results of a study of an object of four megaliths (outcrops) of fairly regular forms on the top of Mount Tuzluk. Outcrops are separated by mutually intersecting passages, forming a shape similar to a cruciform with orientation to
Alekseev, A.A., Potemkina, T.M.
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Physical Review D, 2012 We examine how the (2+1)-dimensional AdS space is covered by the Fefferman-Graham system of coordinates for Minkowski, Rindler and static de Sitter boundary metrics. We find that, in the last two cases, the coordinates do not cover the full AdS space.
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
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