Results 171 to 180 of about 72,602 (336)

The Power of High-precision Broadband Photometry: Tracing the Milky Way Density Profile with Blue Horizontal Branch Stars in the Dark Energy Survey

open access: yesThe Astrophysical Journal
Blue horizontal branch stars (BHBs), excellent distant tracers for probing the Milky Way’s halo density profile, are distinguished in the ${\left(g-r\right)}_{0}$ versus ( i − z ) _0 color space from another class of stars, blue straggler stars.
Fengqing Yu   +11 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Radiative Levitation in Hot Horizontal Branch Stars

open access: yes, 1999
4 pages, contributed talk at the meeting "Spectrophotometric Dating of Stars and Galaxies", Annapolis, USA, May ...
openaire   +2 more sources

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

open access: yesAdvanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen   +10 more
wiley   +1 more source

From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models

open access: yesAdvanced Science, EarlyView.
A comprehensive technology platform enables high‐fidelity, volumetric MALDI imaging of 3D cell cultures by integrating custom embedding molds, a semi‐automated computational framework for 3D reconstruction, voxel‐instead of pixel‐based biomarker discovery, and immersive mixed reality data exploration.
Stefania Alexandra Iakab   +16 more
wiley   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

open access: yesAdvanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li   +12 more
wiley   +1 more source

Ion‐Electron Fusion Transparent Film for Interactive Soft Robotics

open access: yesAdvanced Science, EarlyView.
An ion‐electron fusion transparent film with stable conductivity, high optical transmittance, and a broad linear strain‐sensing range of up to 300% is developed, attributed to the synergistic effects of ion penetration and microcrack design. When applied to soft robots, this film imparts proprioceptive sensing and underwater visible light communication
Zhiqiu Ye   +12 more
wiley   +1 more source

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