Results 231 to 240 of about 575,551 (307)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Hormonal contraception and mental health: a narrative review of screening, monitoring, and patient-centered care for family physicians. [PDF]

Front Psychiatry
Zaidi ARZ, Elhassan H, Syed AM, Waseem N, Muhammed A, Fida L, Fathima S, Taha I, Tannous G, Irshad S, Alghalyini B.   +10 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Pregnancy-Associated Melanoma: A Molecular Reappraisal of the Hormonal Hypothesis, Illustrated by a Postpartum-Persistent Melanoma In Situ. [PDF]

Diagnostics (Basel)
Maghiar L, Iftode A, Neamțu AA, Maghiar TA, Chioibas R, Haj-Ali D, Dumitrescu C, Solomon CN, Iovin VC, Tica O, Huniadi A, Dehelean CA, Brihan I.   +12 more
europepmc   +1 more source

Function-Driven Versus Size-Driven Decision-Making: Real-World Evaluation of the European Society of Endocrinology Criteria in Adrenal Surgery. [PDF]

World J Surg
Buzejic M, Jovanovic M, Rovcanin B, Stojanovic M, Tausanovic K, Slijepcevic N, Ilic J, Zivaljevic V.   +7 more
europepmc   +1 more source

Self-reported racial and ethnic discrimination in patient-provider interactions and the initiation of adjuvant therapies for breast cancer in the pathways study. [PDF]

Breast Cancer Res Treat
Bitsie KR, Pearson TA, Kwan ML, Yaghjyan L, Scarton L, Shariff-Marco S, Andraos TY, D'Addario LL, Kushi LH, Cheng TD.   +9 more
europepmc   +1 more source

Temperature-dependent sex expression in cucurbits and beyond: mechanisms, reproductive plasticity, and breeding implications. [PDF]

Front Plant Sci
Tao Y, Chang C, Yang Y, Huang X, Sun M, Zhu Z, Yang Y, Li R, Liu B, Zhao Q.   +9 more
europepmc   +1 more source