Results 41 to 50 of about 66,570 (338)

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Venous thromboembolism with contraceptive use in females with sickle cell traitAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: Sickle cell trait is the carrier state for sickle cell disease and occurs in 1 in 13 births in Black and African American families. Individuals with sickle cell trait are permitted to serve in the military.
Angela K. Phillips, PhD, APRN, Candy Wilson, PhD, APRN, FAAN, Anwar E. Ahmed, PhD, Arun Shet, MD, PhD, Margaret Bevans, PhD, RN, FAAN   +4 more
doaj   +1 more source

A review of various types of male contraception [PDF]

Journal of Men's Health
Birth control options for men are limited to only condoms and vasectomies. This review focuses on various types of male contraceptives for adequate fertility control and family planning by mutual understanding of couples (healthy family planning ...
Yeonhee Pyo, Ki Han Kwon
doaj   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

Differential Effects of the Hormonal and Copper Intrauterine Device on the Endometrial Transcriptome. [PDF]

, 2020
The contraceptive effectiveness of intrauterine devices (IUDs) has been attributed in part to a foreign body reaction in the endometrium. We performed this study to better understand mechanisms of action of contraceptives of by studying their effects on ...
Averbach, Sarah, Giudice, Linda C, Houshdaran, Sahar, Seidman, Dominika, Smith-McCune, Karen, Takeda, Margaret, Thomas, Reuben   +6 more
core  

Outcomes of Pancreas‐Sparing Total Duodenectomy for Severe Duodenal Polyposis in Patients With Familial Adenomatous Polyposis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Spigelman stage IV duodenal polyposis (SP‐stage IV DP) is associated with high duodenal cancer risk in patients with familial adenomatous polyposis (FAP). This study evaluated the surgical and oncological outcomes of pancreas‐sparing total duodenectomy (PSTD) as a surgical prophylaxis for severe duodenal polyposis in FAP.
Takehiro Shiraishi, Hideyuki Ishida, Takatoshi Matsuyama, Noriyasu Chika, Yoshiko Mori, Norimichi Chiyonobu, Youichi Kumagai, Ibuki Fujinuma, Toshiro Ogura   +8 more
wiley   +1 more source

A longitudinal analysis on the effect of hormone use on allostatic load in perimenopausal women

Aging and Health Research
Background: Allostatic load (AL), a measure of physiologic dysregulation across multiple systems, has been shown to increase as women age and go through menopause. While hormone use has been shown to help with the relief of menopausal symptoms, it is not
Pamela Lamisi Alebna, Joaquin Ignacio Armendano, Nasim Maleki   +2 more
doaj   +1 more source

Perceived impact of the menstrual cycle and hormonal contraceptives on physical exercise and performance in 1,086 athletes from 57 sports

Frontiers in Physiology, 2022
Female athletes train and compete under the potential influence of hormonal fluctuations during the menstrual cycle or during use of various hormonal contraceptives.
Linda Ekenros, Philip von Rosen, Guro Strøm Solli, Guro Strøm Solli, Øyvind Sandbakk, Øyvind Sandbakk, Hans-Christer Holmberg, Hans-Christer Holmberg, Angelica Lindén Hirschberg, Angelica Lindén Hirschberg, Cecilia Fridén, Cecilia Fridén   +11 more
doaj   +1 more source

Role of lactobacilli and lactoferrin in the mucosal cervicovaginal defense [PDF]

, 2018
Human lactoferrin is an iron-binding glycoprotein present at high concentrations in breast milk and colostrum. It is produced by many exocrine glands and widely distributed in a variety of body fluids.
Aagaard, Abramov, Agerberth, Aldunate, Alexander, Allsworth, Anahtar, Ando, Appelmelk, Aroutcheva, Ashida, Baker, Baranger, Beigi, Berlutti, Berlutti, Berlutti, Bradshaw, Bradshaw, Britigan, Brooks, Brotman, Bullen, Byrne, Caccavo, Cauci, Cherpes, Cole, Cole, Conti, Corbin, Corbishley, Cutone, Cutone, De Gregorio, Deese, Delgado-Rizo, Drannik, Elass, Ericksen, Eschenbach, Eslami, Frioni, Fritsch, Gajer, He, He, Hearps, Hedges, Hein, Hemalatha, Hickey, Hiemstra, Hill, Hill, Hudić, Hummelen, Jakobsson, Judd, Kaushic, Kelver, Klebanoff, Kohlhoff, Kościuczuk, Lamont, Larsen, Legrand, Legrand, Leitch, Maggi, Marrazzo, Martin, Martin, Mastromarino, Mastromarino, Mastromarino, Meijerink, Michieli, Moberg, Morrison, Morrison, Nardis, Ness, Niyonsaba, Olmsted, Olmsted, Omata, Ong, O’Hanlon, Paesano, Paesano, Paesano, Paesano, Paesano, Pazgier, Peipert, Peipert, Petrova, Pino, Puddu, Quayle, Rampersauda, Raulston, Ravel, Ravel, Redondo-Lopez, Reghunathan, Rizzo, Rizzo, Roberton, Rosa, Rönnqvist, Santiago, Santiago, Sarkar, Sessa, Shakibaei, Shust, Singh, Singh, Spadaro, Spear, Spurbeck, Srinivasan, Srinivasan, Stallmann, Straub, Stríz, Suzuki, Tachedjian, Teng, Teng, Teng, Tuyama, Valenti, Valenti, Valenti, Valore, Van de Wijgert, Vargas-Villavicencio, Vielfort, Vitali, Walther-António, Ward, Weinberg, Wiesenfeld, Wiesner, Wilson, Wilson, Wilson, Wira, Wira, Wira, Wira, Wu, Yamamoto, Zhou   +156 more
core   +2 more sources

Examining pathways by which socioeconomic instability in adolescence influence sexual health during emerging adulthood in an agricultural setting in California

American Journal of Community Psychology, EarlyView.
Abstract This study investigates the longitudinal impact of socioeconomic instability on teen pregnancy and sexually transmitted infection (STI) diagnosis among adolescents and young adults (AYA) living in an agricultural region and examines pathways including supportive family and social structures, decision making autonomy in romantic relationships ...
Marie C. D. Stoner, Erica N. Browne, Marissa Raymond‐Flesch, Mary Kate Shapley‐ Quinn, Nivedita L. Bhushan, Alondra Jaime‐Aguilar, Carmen Ramirez, Jessica Huante, Daisy Gallardo, Sue Napierala, Megan Comfort, Alexandra M. Minnis   +11 more
wiley   +1 more source