Interference of Binding Protein with Serum Growth Hormone Measurements [PDF]
arXiv, 2014 Measurement of serum growth hormone by mass spectrometry is demonstrated to be unaffected by interferences with growth hormone binding protein as frequently encountered with antibody-based routine test methods and provides an alternative approach, therefore, to acquisition of accurate results.
arxiv
Expert System Based On Neural-Fuzzy Rules for Thyroid Diseases Diagnosis [PDF]
, 2014 The thyroid, an endocrine gland that secretes hormones in the blood, circulates its products to all tissues of the body, where they control vital functions in every cell. Normal levels of thyroid hormone help the brain, heart, intestines, muscles and reproductive system function normally.
arxiv +1 more source
Multi-Task Gaussian Processes and Dilated Convolutional Networks for Reconstruction of Reproductive Hormonal Dynamics [PDF]
arXiv, 2019 We present an end-to-end statistical framework for personalized, accurate, and minimally invasive modeling of female reproductive hormonal patterns. Reconstructing and forecasting the evolution of hormonal dynamics is a challenging task, but a critical one to improve general understanding of the menstrual cycle and personalized detection of potential ...
arxiv
Reduced model for female endocrine dynamics: Validation and functional variations [PDF]
arXiv, 2020 A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle disruption, particularly given the ...
arxiv
Towards Personalized Modeling of the Female Hormonal Cycle: Experiments with Mechanistic Models and Gaussian Processes [PDF]
arXiv, 2017 In this paper, we introduce a novel task for machine learning in healthcare, namely personalized modeling of the female hormonal cycle. The motivation for this work is to model the hormonal cycle and predict its phases in time, both for healthy individuals and for those with disorders of the reproductive system. Because there are individual differences
arxiv
Generalized-Ensemble Simulations of the Human Parathyroid Hormone Fragment PTH(1-34) [PDF]
, 2003 A generalized-ensemble technique, multicanonical sampling, is used to study the folding of a 34-residue human parathyroid hormone fragment. An all-atom model of the peptide is employed and the protein-solvent interactions are approximated by an implicit solvent. Our results demonstrate that generalized-ensemble simulations are well suited to sample low-
arxiv +1 more source
Systems of Delay Differential Equations: Analysis of a model with feedback [PDF]
arXiv, 2016 Self-regulatory models are common in nature, as described e.g. in (\cite{mur}), (\cite{ha}) and (\cite{Gb}).\\ Let us consider a system made up of a number of glands as a motivation. Each gland secretes a hormone that allows secretion in the {next} gland, which successively generates another hormone to stimulate the next one and so on.
arxiv
A Dual-Hormone Closed-Loop Delivery System for Type 1 Diabetes Using Deep Reinforcement Learning [PDF]
arXiv, 2019 We propose a dual-hormone delivery strategy by exploiting deep reinforcement learning (RL) for people with Type 1 Diabetes (T1D). Specifically, double dilated recurrent neural networks (RNN) are used to learn the hormone delivery strategy, trained by a variant of Q-learning, whose inputs are raw data of glucose \& meal carbohydrate and outputs are dual-
arxiv
Local and global analysis of endocrine regulation as a non-cyclic feedback system [PDF]
, 2016 To understand the sophisticated control mechanisms of the human's endocrine system is a challenging task that is a crucial step towards precise medical treatment of many disfunctions and diseases. Although mathematical models describing the endocrine system as a whole are still elusive, recently some substantial progress has been made in analyzing ...
arxiv +1 more source
Utilizing of protein splicing phenomenon for optimization of obtaining and purification of the recombinant human growth hormone [PDF]
Europ J Medic Res., 2006, Oct. 8, vol.11 - p. 128-129, 2006 Protein splicing is a post-translational autocatalystic excision of internal protein sequence (intein) with the subsequent ligation of the flanking polypeptides (exteins). The high specificity of excision ensured by intein makes it possible to use a phenomenon of protein splicing for the biotechnology purposes.
arxiv