Results 101 to 110 of about 93,399 (264)

CLINICAL CASE ADRENOGENITAL SYNDROME

open access: yesUkrainian Scientific Medical Youth Journal, 2017
The article describes clinical case Adrenogenital syndrome in child study hormonal and physical state which facilitated the correct treatment and solving legal issues for further life through legal sex change.
V.M. Yerokhovych, M.I. Bobryk
doaj  

Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]

open access: yes, 2015
Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo   +6 more
core   +3 more sources

TSH Ligand‐Based CAR‐T Cell Effectively Eradicates TSHR‐Positive Thyroid Cancer with Favorable Safety Profile

open access: yesAdvanced Science, EarlyView.
TSHR is highly expressed in differentiated thyroid cancer (DTC), making it an ideal target for adoptive immune cell therapy. A novel Ligand‐based TSH‐CAR‐T cell approach effectively eradicated TSHR‐positive thyroid tumors in vitro and accomplished full remission in tumor models with favorable safety profile, highlighting that TSH‐CAR‐T cells could ...
Fei Wang   +10 more
wiley   +1 more source

Are patients with primary hypothyroidism in India receiving appropriate thyroxine replacement? An observational study

open access: yesIndian Journal of Endocrinology and Metabolism, 2014
Background: A large proportion of patients worldwide under treatment for hypothyroidism with thyroxine show suboptimal Thyroid Stimulating Hormone (TSH) values.
Ambrish Mithal   +2 more
doaj   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

open access: yesAdvanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun   +9 more
wiley   +1 more source

Sensory neuron LKB1 mediates ovarian and reproductive function

open access: yesScientific Reports
Treatments for reproductive disorders in women consist of hormone replacement therapy, which have negative side effects that impact health, spurring the need to understand new mechanisms to employ new therapeutic strategies.
Melissa E Lenert   +2 more
doaj   +1 more source

Female Reproductive Factors and Differentiated Thyroid Cancer

open access: yesFrontiers in Endocrinology, 2017
Differentiated thyroid cancer (DTC) is markedly more common in women than men, the highest female-to-male ratio being recorded during the reproductive period.
Mariacarla Moleti   +4 more
doaj   +1 more source

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

open access: yesAdvanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang   +13 more
wiley   +1 more source

Rationale and design of PATRO Adults, a multicentre, noninterventional study of the long-term efficacy and safety of Omnitrope for the treatment of adult patients with growth hormone deficiency

open access: yesTherapeutic Advances in Endocrinology and Metabolism, 2012
Objective : To describe the rationale and design of PATRO Adults, a postmarketing surveillance study of the long-term efficacy and safety of somatropin (Omnitrope ® ) for the treatment of adult patients with growth hormone deficiency (GHD).
Paolo Beck-Peccoz   +4 more
doaj   +1 more source

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