Results 171 to 180 of about 95,214 (265)

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, EarlyView.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Case Report: Laparoscopic vaginoplasty in a case of partial androgen insensitivity syndrome and a literature review of 16 cases in China. [PDF]

Front Surg
Qin H, Liu H, Liu Q, Li B.
europepmc   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Determinants of QTc Interval Prolongation in Patients with Hypopituitarism and Other Pituitary Disorders. [PDF]

Biomedicines
Gasco V, Cuboni D, Siclari S, Mocellini F, Sibilla M, Grottoli S, Ghigo E, Maccario M.   +7 more
europepmc   +1 more source

PSMD12 Overexpression Promotes Lung Adenocarcinoma Progression via Ubiquitin–Proteasome Pathway Dysregulation

Cancer Science, EarlyView.
PSMD12, located on the frequently amplified 17q region in LUAD, is upregulated in tumors and associated with poor prognosis and advanced stage. Functional studies revealed that PSMD12 promotes cell proliferation and G2/M transition by inhibiting CDK1 ubiquitination and stabilizing CDK1.
Yuya Ono, Hajime Otsu, Takaaki Masuda, Keisuke Kosai, Shohei Shibuta, Kosuke Hirose, Takashi Ofuchi, Yuki Ando, Koto Kawata, Yasuo Tsuda, Yusuke Yonemura, Taro Tobo, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Koshi Mimori   +14 more
wiley   +1 more source

Postoperative immune-related adverse events after conversion surgery following induction immune checkpoint inhibitor-combined chemotherapy in patients with unresectable esophagogastric junction carcinoma: a report of two cases. [PDF]

J Cardiothorac Surg
Nakashima R, Koyanagi K, Yamamoto M, Kazuno A, Shoji Y, Ninomiya Y, Kanamori K, Tajima K, Ogimi M, Nishi T, Mori M.   +10 more
europepmc   +1 more source

Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer

Cancer Science, EarlyView.
Persistent overweight or obesity, and BMI gain from normal to overweight or obesity, were consistently associated with reduced lung cancer risk, with stronger associations among men and ever smokers. Persistent underweight and BMI loss were associated with increased lung cancer risk, particularly in men. The protective effect of obesity and BMI gain is
Su Youn Nam, Junwoo Jo, Sun Ha Choi
wiley   +1 more source

Pituitary Apoplexy: A Case Series. [PDF]

Cureus
Meher D, Agarwal V, Das S, Choudhury A, Sahu SK, Sahoo D, Prusty B, Das B, Chappalagavi AS, Gupta S.   +9 more
europepmc   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Reproductive dysfunction in hemodialysis: endocrine mechanisms, clinical features, and therapeutic approaches. [PDF]

Ren Fail
Gou W, Xue C, Zeng F, Zhu C, Yang B.
europepmc   +1 more source