Results 171 to 180 of about 93,399 (264)

Impact of sex on outcomes in septic shock patients treated with hydrocortisone. [PDF]

Sci Rep
Moustafa HAM, Montasser M, Ahmed I, Mansy AEA, Habib T.   +4 more
europepmc   +1 more source

“It's just us”: Families' experiences with temporary tube feeding

Nutrition in Clinical Practice, EarlyView.
Abstract Background Children with temporary feeding tubes are discharged home with increasing frequency, yet little is known about how families adapt and manage in their home environment. Whereas the physical side effects of temporary feeding tubes are well documented, the psychosocial impact on families remains underresearched. Understanding families'
Claire Reilly, Jeanne Marshall, Jasmine Foley, Nikhil Thapar, Rebecca Packer   +4 more
wiley   +1 more source

Evaluating Sex Disparity in Pancreatic Ductal Adenocarcinoma Risk in the UK Biobank Cohort. [PDF]

United European Gastroenterol J
Peduzzi G, Pellungrini R, Archibugi L, Canzian F, Rizzato C, Capurso G, Campa D.   +6 more
europepmc   +1 more source

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide (NPY/AgRP) Neurons

Obesity, EarlyView.
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W. Williams, Natalie J. Michael   +4 more
wiley   +1 more source

Disparities in Growth Hormone Deficiency Screening, Evaluation, Diagnosis, and Treatment Among At‐Risk Childhood Cancer Survivors in the US

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Minoritized childhood cancer survivors (CCS) may encounter barriers to timely late effects surveillance. We aimed to evaluate clinical and demographic differences in the likelihood of, and timing to, growth hormone deficiency (GHD) screening, evaluation, diagnosis, and treatment among at‐risk CCS treated with radiation therapy (RT).
Fulfilled Ighalo, Meghan Craven, M. Fatih Okcu, Austin Brown, Arnold C. Paulino, David Steffin, Maria Gramatges, Vincent E. Horne   +7 more
wiley   +1 more source

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source

The interdisciplinary management of craniopharyngioma - practice patterns, outcomes, and insights. [PDF]

BMC Cancer
Haselmann J, Roohani S, Wasilewski D, Onken J, Capper D, Kaul D, Ehret F.   +6 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Analysis of related factors of biochemical pregnancy loss in single blastocyst transfer in the hormone replacement protocol frozen-thawed cycle. [PDF]

BMC Pregnancy Childbirth
Mei J, Dong D, Fu Q, Li L, Huang C, Zhu Y.   +5 more
europepmc   +1 more source

A Combined Model‐Based Meta‐Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model‐based meta‐analysis allows integration of aggregated‐level data (AD) from different clinical trials in one model to assess population efficacy/safety. However, AD is limited in individual‐level information, while individual‐patient‐level data (IPD) are hard to obtain. Combined modeling may take advantage of both sources.
Liang Yang, Carolina Llanos‐Paez, Shuying Yang, Claire Ambery, Alienor Berges, Maria C. Kjellsson, Mats O. Karlsson   +6 more
wiley   +1 more source