Results 261 to 270 of about 1,211,511 (356)

Horses for courses [PDF]

open access: yesEpidemiology and Psychiatric Sciences, 2012
openaire   +3 more sources

TRiC Is a Structural Component of Mammalian Sperm Axonemes

open access: yesCytoskeleton, EarlyView.
ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Alan Brown   +3 more
wiley   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami   +2 more
wiley   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy