Results 261 to 270 of about 9,247,528 (359)

Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element

open access: yesAging Cell, EarlyView.
Proposed TPE‐OLD model. TPE‐OLD genes are defined by a progressive modulation of gene expression following telomere attrition. In our study, focusing on the molecular mechanism of TPE‐OLD, we found that the TPE‐OLD loop requires a cis‐signature corresponding to a newly evolved Alu repeats (AluY). The Alu repeat can be either in an intergenic region, as
Raphaël Chevalier   +6 more
wiley   +1 more source

Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation

open access: yesAging Cell, EarlyView.
This study identifies a macrophage subpopulation, Mac_1, that promotes skeletal muscle regeneration by enhancing muscle stem cell proliferation through HGF/MET signaling. A 3D‐muscle organoid model confirmed the critical role of HGF/MET signaling in regeneration, highlighting a potential therapeutic target for age‐related impairment of skeletal muscle ...
Hiroyuki Koike   +5 more
wiley   +1 more source

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

open access: yesAging Cell, EarlyView.
Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targets collagen remodeling and stem cell function‐related genes.
Toby L. Chambers   +16 more
wiley   +1 more source

Deltaviruses spread through a viral Trojan Horse

open access: yes
McKellar J   +14 more
europepmc   +1 more source

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