Results 131 to 140 of about 3,337,856 (280)

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Evaluation of inhaled antimicrobials as adjunctive therapy in the treatment of ventilator-associated pneumonia

Egyptian Journal of Chest Disease and Tuberculosis
Background Nebulized antibiotics show notable efficacy owing to their significant local concentrations and provide safety with low blood levels. In addition to these measurements, duration of hospitalization, ICU stay, days used to administer antibiotics,
Adel M. Saeed, Hala M. Salem, Riham H. Raafat, Sarah N. Badry   +3 more
doaj   +1 more source

Discrepant Urinary Findings Between Dipstick Protein and Sulfosalicylic Acid Test in a Patient With Hyaline Casts: A Case Report

Journal of Clinical Laboratory Analysis, EarlyView.
In this post‐transplant patient, increased hyaline casts with negative dipstick protein but positive SSA testing occurred during evolving acute kidney injury and resolved with renal recovery. This discordant urinalysis pattern may warrant confirmatory protein testing and correlation with serial renal function in patients at high risk of AKI.
Yifei Jia, Binquan Chu, Fengjun Chen, Xiangyu Zhu, Chen Hang, Xiaoling Yu, Jinpiao Lin   +6 more
wiley   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Comparison of machine learning methods for prediction of venous thromboembolism among hospitalized adults

Journal of Hospital Medicine, EarlyView.
Abstract Background Hospital‐acquired venous thromboembolism (HA‐VTE) is a significant cause of morbidity and mortality among hospitalized adults. Accurate prediction of HA‐VTE is crucial for timely intervention and prevention. While logistic regression is widely used for the development of clinical prediction models, there is ongoing interest in the ...
Yeji Ko, Benjamin French, Jonathan S. Schildcrout, Merna El‐Rifai, Adam Wright, Benjamin F. Tillman, Amanda S. Mixon, Henry J. Domenico   +7 more
wiley   +1 more source

Clinicians' and patients' perspectives of a mobility technician role in the hospital to promote ambulation: A qualitative study

Journal of Hospital Medicine, EarlyView.
Abstract Background Hospitalized older patients are predominantly sedentary, risking functional decline. Nurses and physical therapists are primarily responsible for mobility but have many competing demands. Objectives To explore clinicians' and patients' perceptions of mobility technicians dedicated to support inpatient ambulation.
Jordan M. Alpert, Anya Patel, Jacqueline Fox, Holly Renner, Joshua K. Johnson, Quinn R. Pack, Robert J. Fox, Christian N. Burchill, Lee Anne Siegmund, Mary Stilphen, Peter K. Lindenauer, Michael B. Rothberg   +11 more
wiley   +1 more source

The association between sociodemographic and clinical factors and outcomes among inpatients with community‐acquired pneumonia

Journal of Hospital Medicine, EarlyView.
Abstract Background Community‐acquired pneumonia (CAP) is a leading cause of hospitalization and mortality. The influence of sociodemographic characteristics on adverse outcomes in adults hospitalized with CAP remains poorly understood, particularly for patients younger than 65.
Farhana Islam, Surain B. Roberts, Sarah L. Malecki, Anne Loffler, Leo Hersi, Anthony D. Bai, Amol A. Verma, Fahad Razak, Peter J. Gill, Sanjay Mahant   +9 more
wiley   +1 more source

Beyond the Symptoms: Exploring the Clinical, Bacteriological, and Radiological Profiles and Outcomes of Community-Acquired, Hospital-Acquired, and Ventilator-Associated Pneumonia in a Tertiary Care Setting

JK Science
Background: The lower respiratory tract infections (LRTIs), including pneumonia, are the fourth most common cause of mortality globally and the second most frequent reason for years of life lost.
Shashi Bhusan Rao Kelli, Ram B. Deoskar, Gouri Mohan Bhoite, Abdulrahaman Abubakar Momin   +3 more
doaj  

Variation in blood culture testing in children hospitalized with three common infections

Journal of Hospital Medicine, EarlyView.
Abstract Background Routine blood culture (BCx) testing in uncomplicated community‐acquired pneumonia (CAP), skin and soft tissue infections (SSTI), and urinary tract infections (UTI) has demonstrated low clinical utility. Objectives To evaluate hospital‐level BCx testing trends and their association with clinical outcomes for children hospitalized ...
Smit Shah, Jennifer L. Goldman, Matt Hall, John R. Stephens, Jillian M. Cotter, Samantha A. House, Matthew J. Molloy, Michelle Polich, Michael J. Steiner, Michael J. Tchou, Ronald J. Teufel II, Irma T. Ugalde, Andrew G. Yu, Jessica L. Markham   +13 more
wiley   +1 more source

Hospital-acquired pneumonia in intensive care patients

, 2013
The present thesis describes the incidence and risk factors for pneumonia and especially ventilator-associated pneumonia (VAP) among Intensive Care Unit (ICU) patients. Bacteria in samples from the lower respiratory tract of patients receiving mechanical
Petra Hyllienmark (18647125)
core   +1 more source