Results 211 to 220 of about 34,918,071 (337)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Hypertension and its associated risk factors in tuberculosis patients: A hospital based cross-sectional study. [PDF]

Asia Pac J Clin Nutr
Tan Y, Gao X, Li Y, Li X, Liu Y, Li X, Yan T, Yan Q, Schouten EG, Kok FJ, Wang Q.   +10 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Effectiveness of a Hospital-Based Antimicrobial Stewardship Program: A Three-Year Observational Study. [PDF]

Med Princ Pract
Guchhait P, Saha T, Chaudhuri BN, Das A, Banerjee RD, Mukherjee S, Das S.   +6 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Characteristics of a three-pronged continuum of care model for hospital-based violence intervention. [PDF]

Trauma Surg Acute Care Open
Castater C, Hart L, Metchik A, Jackson K, Wright R, Cave N, Alexander C, Clemons J, Sarumi P, Smith RN.   +9 more
europepmc   +1 more source

Neonatal sepsis in South Asia: huge burden and spiralling antimicrobial resistance. [PDF]

, 2019
Agarwal, R, Chaurasia, S, Ellis, S, Sankar, MJ, Sharland, M, Sivanandan, S   +5 more
core   +1 more source

What are the views of hospital-based generalist palliative care professionals on what facilitates or hinders collaboration with in-patient specialist palliative care teams? A systematically constructed narrative synthesis

Palliative Medicine, 2016
Janice I. Firn, N. Preston, C. Walshe
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Epidemiology of pediatric road traffic injuries: a multicenter hospital-based study in Ghana. [PDF]

Inj Epidemiol
Appiah AB, Wilson ML, Dambach P, MohammadNamdar M, Buunaaim ADB, Alatiiga JA, Ativor V, Donkor P, Mock C.   +8 more
europepmc   +1 more source