Results 161 to 170 of about 6,331 (227)

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang   +17 more
wiley   +1 more source

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

open access: yesArthritis &Rheumatology, Volume 78, Issue 5, Page 1045-1061, May 2026.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin   +15 more
wiley   +1 more source

Is there a ‘learning effect’ on serial lung function assessments?

open access: yes
Experimental Physiology, EarlyView.
Rie Skovly Thomsen   +2 more
wiley   +1 more source

Understanding the influence of transfusion and blood loss on tranexamic acid concentration in scoliosis surgery with blood loss

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1397-1405, May 2026.
Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá   +4 more
wiley   +1 more source

Biphasic, Refractory, and Persistent Anaphylaxis in Children

open access: yesClinical and Translational Allergy, Volume 16, Issue 5, May 2026.
ABSTRACT Background A Delphi consensus report refined anaphylaxis phenotypes as biphasic, refractory, and persistent anaphylaxis (BA, RA, and PA). To date, no study in either pediatric or adult populations has comprehensively evaluated the full spectrum of anaphylaxis phenotypes as outlined in this consensus.
Gizem Koken   +8 more
wiley   +1 more source

Advancing Pharmacoequity Globally: Reflections from the ASCPT Development, Regulatory, and Outcomes Network

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1156-1159, May 2026.
ASCPT has a mission to advance clinical pharmacology and translational sciences to reduce health disparities. The development, regulatory, and outcomes (DRO) network within ASCPT strives to advance pharmacoequity globally. Pharmacoequity, coined by Utibe Essien (2021), is the principle that all individuals, regardless of race, ethnicity, geography, or ...
Priya Jayachandran   +13 more
wiley   +1 more source

Aspectos clí­nicos de pacientes psicogeriátricos internados em um Hospital Dia na cidade de São Paulo

open access: yes, 2018
Introdução: O aumento da população acima dos sessenta anos de idade e as caracterí­sticas especí­ficas dos transtornos psiquiátricos nesta faixa etária estimulam o surgimento de serviços psicogeriátricos no Brasil. Objetivos: Descrever alguns aspectos clí­nicos e sócio-demográficos de pacientes admitidosno hospital dia da Unidade de Idosos (UNID ...
Tamai, Sérgio   +5 more
openaire   +1 more source

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