Results 211 to 220 of about 88,107,133 (293)

A Neutrophil Membrane‐Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age‐Dependent Perioperative Neurocognitive Disorders

Advanced Science, EarlyView.
This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang, Jiahui Cheng, Huan Xu, Qiang Zhang, Xiao Zhang, Ye Liu, Yizhe Zhang, Wanbing Dai, Zhi Xiong, Linghuan Guo, Lingling Xu, Wen Wang, Xin Xu, Yan Zhou, Weifeng Yu, Bo Li, Diansan Su, Daxiang Wen   +17 more
wiley   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Empowering Patients and Families Across the Continuum of Care: From Early Risk Detection to Integrated Home Healthcare and Hospital-at-Home Models. [PDF]

J Nurs Res
Chien LY.
europepmc   +1 more source

Rural Labor Supply and Economic Opportunities: Commuting, Migration, Tariffs, and Immigration

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Some rural counties remain dependent on agricultural or manufacturing jobs, but an increasing proportion have diversified economics. Rural counties also differ in their abilities to commute to an urban market characterized by higher wages and labor productivity.
Peter F. Orazem, Mary C. Ahearn
wiley   +1 more source

Assessing Stroke Caregivers' Preparedness and Associated Factors for Patients' Transition From Hospital to Home. [PDF]

Stroke Res Treat
Babkair LA, Abujabal M, Basha MA, Saeed M, Alyafee RM, Alsolami NJ, Algarni SS.   +6 more
europepmc   +1 more source

The Effect of SNAP Purchasing Power on Diet Quality

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The Supplemental Nutrition Assistance Program (SNAP) benefits millions of eligible low‐income Americans by increasing access to food, helping to reduce food insecurity. Previous studies have documented that the geographical variation in local food prices leads to significant differences in SNAP's purchasing power.
Farah Khan, Augustine Denteh
wiley   +1 more source

Beyond blood gases: diaphragm-guided sequential non-invasive ventilation for COPD with type II respiratory failure. [PDF]

Front Med (Lausanne)
Wang Y, Yao L, Xiao Q, Tan Y.
europepmc   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source

Hospital-to-Home Neurological Transition Care: A Scoping Review Across Selected Chronic Neurological Disorders. [PDF]

Med Sci (Basel)
Calabrò RS, Calderone A, Ravi D, Galipò C, Crupi MF, Quartarone A.   +5 more
europepmc   +1 more source