Results 161 to 170 of about 9,194,995 (243)

There is no place like home: patient perspectives on mobility outside the home during hospital-at-home care- a qualitative study. [PDF]

Ann Med
Ong CY, Tan LML, Low SG, Tan AHD, Wong JSH.   +4 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Prehospital Transfusion With Red Blood Cells and Fresh Plasma in Helicopter Emergency Medical Services. [PDF]

Acta Anaesthesiol Scand
Andersen JB, Risgaard B, Schou R, Dahl M, Hansen TM, Johansson PI, Erikstrup C, Steinmetz J, Fenger-Eriksen C.   +8 more
europepmc   +1 more source

Hospital Variation in Labor After Cesarean and Vaginal Birth After Cesarean in Massachusetts, 2012-2022. [PDF]

O G Open
Attanasio LB, Kim S, Laws H, Goff SL, Srinivas SK.   +4 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Criteria for Safe Hospital Discharge in Bronchiolitis: A Systematic Review. [PDF]

Emerg Med Australas
Borland ML, Loveys K, Babl FE, Cotterell E, Haskell L, O'Brien S, Oakley E, Tavender EJ, Wilson CL, Dalziel SR, Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network.   +10 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Modbury Hospital Development plan photo 3

Black and white photo of 3 people examining plans for future buildings at Modbury ...
Modbury Hospital
core  

Correction: Angiography- and IVUS-tip-detection-guided 3D wiring for CTO and non-CTO percutaneous coronary interventions. [PDF]

Cardiovasc Interv Ther
Okamura A, Yoshikawa R, Tanaka K, Suzuki S, Ishikawa M, Nagai H, Yamasaki T, Yamaji K, Kawamura K, Okamoto N, Ishihara T, Nagamatsu W, Serikawa T, Ito Y, Watanabe H.   +14 more
europepmc   +1 more source