Results 111 to 120 of about 11,396,055 (313)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Hypoalbuminemia: a Hospital Based Study [PDF]

open access: yes, 2012
Hypoalbuminemia occurs in a variety of disease states and is associated with an increased rate of complications during hospitalization, resulting in an increased length of stay.
H, S. A. (Siddiqui)   +2 more
core  

Stable Matching under Matroid Rank Valuations [PDF]

open access: yesarXiv
We study a two-sided matching model where one side of the market (hospitals) has combinatorial preferences over the other side (doctors). Specifically, we consider the setting where hospitals have matroid rank valuations over the doctors, and doctors have either ordinal or cardinal unit-demand valuations over the hospitals.
arxiv  

Conferencias anatomoclinicas

open access: yesRevista de la Facultad de Medicina, 1953
Caso número siete: La enferma ingresa a1 Servicio de Clínica Medica del Profesor Edmundo Rico el 30 de junio de 1951 por presentar fiebre y dolor abdominal difuso / Caso número ocho: EI enfermo ingresa al Servicio de Clínica Semiológica el 2 de ...
San Juan de Dios Hospital de
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Conferencias anatomoclinicas: caso No. quince

open access: yesRevista de la Facultad de Medicina, 1955
L. E. M.: 50 años. Lugar de Origen: Cucunubá. Lugar de Procedencia: Tausa. Servicio del Profesor Edmundo Rico. NOTA CLINICA: El enfermo ingresa al Servicio de Clínica Médica el 17 de enero de 1952 por presentar disnea de esfuerzo, tos frecuente con ...
San Juan de Dios Hospital de
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Assessment of Technical Efficiency in the Moroccan Public Hospital Network: Using the DEA Method [PDF]

open access: yesarXiv
Background: The public hospital network in Morocco plays a crucial role in providing healthcare services. However, this network faces challenges in terms of technical efficiency in healthcare management. Objectives: This study aimed to assess the technical efficiency of the public hospital network in Morocco.
arxiv  

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