Results 111 to 120 of about 11,792,242 (280)

Barnes Hospital Bulletin [PDF]

open access: yes, 1981
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1188/thumbnail ...

core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Barnes Hospital Record [PDF]

open access: yes, 1962
https://digitalcommons.wustl.edu/bjc_barnes_record/1176/thumbnail ...

core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

open access: yes, 1968
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1041/thumbnail ...

core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Conferencias Anatomopatológicas

open access: yesRevista de la Facultad de Medicina, 1953
Caso número cuatro: La enferma ingresa al servicio de Clínica Semiológica el 5 de abril de 1951, por presentar ictericia, fiebre, dolor abdominal intenso, localizado principalmente en el hipocondrio derecho, nauseas, vomitus y cefalea / Caso número ...
San Juan de Dios Hospital de
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Anais da 44ª Semana Científica do HCPA

open access: yesClinical and Biomedical Research
A Semana Científica é nosso maior evento científico, um fórum anual para divulgar a pesquisa que aqui realizamos no dia-a-dia e para congregar estudantes de graduação e pós-graduação, docentes e profissionais da nossa casa e de outras ...
Hospital de Clínicas de Porto Alegre
doaj   +2 more sources

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