Results 151 to 160 of about 11,396,055 (313)
Molecular Oncology, EarlyView.Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns +4 more
wiley +1 more source
An Interactive Decision-Support Dashboard for Optimal Hospital Capacity Management [PDF]
arXivData-driven optimization models have the potential to significantly improve hospital capacity management, particularly during demand surges, when effective allocation of capacity is most critical and challenging. However, integrating models into existing processes in a way that provides value requires recognizing that hospital administrators are ...
arxiv
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Anais da 42° Semana Científica do HCPA
Clinical and Biomedical ResearchA Semana Científica é o maior evento científico anual do Hospital de Clínicas de Porto Alegre, um fórum para divulgar a pesquisa que aqui realizamos no dia-a-dia e para congregar estudantes de graduação e pós-graduação, docentes e profissionais de ...
Hospital de Clínicas de Porto Alegre
doaj +2 more sources
Introductory Lecture to a Course of Lectures on the Pathology and Treatment of Insanity, delivered at St. Luke's Hospital, in the Months of May and June, 1855 [PDF]
Alex Sutherland
openalex +1 more source