Results 151 to 160 of about 6,669,512 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

THE CLINICAL STUDY ON ABDOMINAL TUBOLIGATION UNDER ACUPUNCTURE ANESTHESIA

针刺研究, 1988
Wang Shuyi (The first People's Hospital, Huaiyin, Jiangsu)Xu Ziyu (Kunsan County Hospital   +2 more
doaj  

Interhospital Transfers in ICU- and Non-ICU-Treated Sepsis Patients in Germany Between 2016 and 2019. [PDF]

Crit Care Explor
Fleischmann-Struzek C, Ruhnke T, Freytag A, Dutschkus F, Kochanek M, Swart E, Dröge P, Dennler U, Pletz MW, Rose N.   +9 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An updated systematic review of the impact of volume of surgery and specialization in Norwood procedure. [PDF]

BMC Pediatr
Pachanov A, Zhang Z, Munschek S, Asfour B, Mathes T, Pieper D.   +5 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion: A Randomized Clinical Trial.

JAMA Neurol
Inoue M, Hirano T, Fukuda-Doi M, Kawano H, Tanaka K, Sakai N, Koga M, Iwasaki K, Yoshie T, Kamogawa N, Ihara M, Ohta T, Chin M, Kimura N, Kimura K, Tateishi Y, Terasaki T, Hatano T, Kuwashiro T, Yoshimura S, Ueda T, Nagata E, Nagakane Y, Takahashi S, Miyashita F, Sonoda K, Fukuda K, Tanaka K, Une Y, Kobari S, Nagao T, Sasaki M, Yamamoto H, Toyoda K, T-FLAVOR trial Investigators.   +34 more
europepmc   +1 more source

Preoperative Risk Evaluation for Cancer Treatment (PREdiCT): protocol for an international cohort study evaluating a trimodal screening tool to predict outcomes following gastrointestinal cancer surgery. [PDF]

BMJ Open
Reeves J, Koh C, Alexander K, Solomon M, Karunaratne S, Petridis A, Carey S, Dhillon H, White K, Pillinger N, Gillis C, Hirst N, Shadid Z, Rahman MI, Boden I, Mahoney A, Woodfield J, Vagg D, De Boer HD, Sutton P, Pereira L, Drummond-Lage AP, Mcloughlin S, Alvarez A, Pirie K, Hii MW, Suliman A, Uçaner B, Schizas D, Nassim K, Albatool R, Ali K, Triantafyllou T, Styliana A, Merlini I, Van Daele E, Mulita F, Bell M, Martinez-Palli G, Koch C, Falconi M, Garmanova T, Deng N, Tirelli F, Lubbers T, Chwat C, Costales A, Hanna NM, Petrova A, Khamees A, Beard D, Granger CL, PREdiCT Study Investigators, Steffens D.   +53 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Quality education initiative to reduce pressure ulcers in high-risk-admitted patients in low-resource settings. [PDF]

BMJ Open Qual
Khattak AF, Hussain S, Ahmad B, Khattak M, Afridi WV, Khan B.   +5 more
europepmc   +1 more source