Results 51 to 60 of about 14,035,857 (361)

Children\u27s Hospital [PDF]

, 2014
https://scholarlyworks.lvhn.org/childrens-hospital/1001/thumbnail ...
Lehigh Valley Health Network
core   +2 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Comprehensive geriatric assessment for older adults admitted to hospital.

Cochrane Database of Systematic Reviews, 2017
BACKGROUND Comprehensive geriatric assessment (CGA) is a multi-dimensional, multi-disciplinary diagnostic and therapeutic process conducted to determine the medical, mental, and functional problems of older people with frailty so that a co-ordinated and ...
G. Ellis, Michael P. Gardner, A. Tsiachristas, P. Langhorne, Órlaith Burke, R. Harwood, S. Conroy, T. Kircher, D. Somme, I. Saltvedt, H. Wald, D. O’Neill, D. Robinson, S. Shepperd   +13 more
semanticscholar   +1 more source

Estimating Risk-Adjusted Hospital Performance [PDF]

arXiv, 2020
The quality of healthcare provided by hospitals is subject to considerable variability. Consequently, accurate measurements of hospital performance are essential for various decision-makers, including patients, hospital managers and health insurers. Hospital performance is assessed via the health outcomes of their patients.
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

A Randomized Trial of Epinephrine in Out‐of‐Hospital Cardiac Arrest

New England Journal of Medicine, 2018
BACKGROUND Concern about the use of epinephrine as a treatment for out‐of‐hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebocontrolled trial to determine whether the use of epinephrine is safe and ...
G. Perkins, Chen Ji, C. Deakin, T. Quinn, J. Nolan, Charlotte Scomparin, Scott E Regan, John Long, A. Slowther, H. Pocock, J. Black, F. Moore, R. Fothergill, N. Rees, Lyndsey O’Shea, Mark Docherty, I. Gunson, Kyee Han, Karl Charlton, J. Finn, S. Petrou, N. Stallard, S. Gates, R. Lall   +23 more
semanticscholar   +1 more source

Hospital Quality Risk Standardization via Approximate Balancing Weights [PDF]

arXiv, 2020
Comparing outcomes across hospitals, often to identify underperforming hospitals, is a critical task in health services research. However, naive comparisons of average outcomes, such as surgery complication rates, can be misleading because hospital case mixes differ -- a hospital's overall complication rate may be lower due to more effective treatments
arxiv  

Mortality Rate Estimation and Standardization for Public Reporting: Medicare's Hospital Compare [PDF]

Journal of the American Statistical Association (2017), 112:519, 933-947, 2015
Bayesian models are increasing fit to large administrative data sets and then used to make individualized recommendations. For instance, Medicare's Hospital Compare webpage provides information to patients about specific hospital mortality rates for a heart attack or Acute Myocardial Infarction (AMI).
arxiv   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source