Results 61 to 70 of about 11,785,950 (341)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Annual report of the Massachusetts Homeopathic Hospital. [PDF]

, 1871
Annual report of the Massachusetts Homeopathic ...
Board of Trustees, Massachusetts Homeopathic Hospital
core  

Conferencias anatomoclínicas: caso no. veinte

Revista de la Facultad de Medicina, 1955
S. L. 16 años. Ciudad de origen y procedencia: San Martín. Servicio del Prof. Luis María Salgar. NOTA CLINICA: La paciente ingresa al Servicio de Clínica Médica el 25 de Octubre de 1951 con disnea de esfuerzo y de decúbito, tos con expectoración ...
San Juan de Dios Hospital
doaj  

HOSPITALISM: [PDF]

The Lancet, 1874
n ...
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Conferencias anatomoclínicas: caso no. veinticuatro

Revista de la Facultad de Medicina, 1955
Se hace una revisión de un caso clínico presentado en el Hospital San Juan de Dios, Bogotá.
San Juan de Dios Hospital
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Evans Medicine [PDF]

, 1990
Newsletter of the Evans Memorial Department of Clinical Research and Preventive Medicine at University ...
University Hospital, Evans Memorial Department of Clinical Research and Preventive Medicine
core  

Conferencias anatomoclínicas: caso no. veintidos

Revista de la Facultad de Medicina, 1955
E. A. v de C. 52 años. Ciudad de origen: Girardot. Ciudad de procedencia: Bogotá. Servicio del Profesor Guerrero Izquierdo. NOTA CLINICA: La enferma ingresa al Servicio de Urgencia el 13 de mayo de 1952 a las 5 :30 p. m.
San Juan de Dios Hospital
doaj