Results 61 to 70 of about 15,847,430 (379)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Conferencias anatomoclinicas

Revista de la Facultad de Medicina, 1954
Caso número once: EI enfermo ingresa al Servicio de Clínica Semiológica del Profesor Forero Villaveces el 20 de agosto de 1951, por presentar anorexia, dolor epigástrico, vómito postprandial, flatulencia, enflaquecimiento progresivo y gran astenia / Caso
San Juan de Dios Hospital
doaj   +2 more sources

Cangrelor en el intervencionismo coronario percutáneo: una «nueva» arma del arsenal terapéutico antitrombótico

REC: Interventional Cardiology, 2020
Durante la segunda mitad de 2019 se inició en nuestro país la comercialización del cangrelor, un «nuevo» antiagregante plaquetario con características farmacológicas singulares que lo hacen atractivo para determinadas situaciones clínicas en el contexto ...
José Luis Ferreiro, Joan Antoni Gómez-Hospital   +1 more
doaj   +1 more source

Reporting Sexual Assault Victimizations to Law Enforcement [PDF]

, 2007
As part of a larger study examining the characteristics of sexual assault victimizations in Alaska as observed and recorded by sexual assault nurse examiners, 101 patients in Bethel, Fairbanks, Kodiak, Kotzebue, Nome, and Soldotna provided information ...
Central Peninsula General Hospital, Fairbanks Memorial Hospital, Henry, Tara, Maniilaq Association, Norton Sound Health Corporation, Providence Kodiak Island Medical Center, Rosay, André B., Yukon-Kuskokwim Health Corporation   +7 more
core  

First hospital outbreak of the globally emerging Candida auris in a European hospital

Antimicrobial Resistance and Infection Control, 2016
Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016. This is the first report of C.
S. Schelenz, F. Hagen, J. Rhodes, A. Abdolrasouli, A. Chowdhary, A. Hall, Lisa Ryan, Joanne Shackleton, R. Trimlett, J. Meis, D. Armstrong-James, Matthew Fisher   +11 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1977
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1143/thumbnail ...

core   +4 more sources

Conferencias anatomoclínicas: caso no. diez y nueve

Revista de la Facultad de Medicina, 1955
z. J. M. 60 años. Ciudad de origen: Simijaca. Ciudad de procedencia: Tena. Servicio del Prof. Carlos Trujillo Gutiérrez. NOTA CLINICA: El enfermo ingresa al Servicio de Clínica quirúrgica del Prof.
San Juan de Dios Hospital
doaj  

The Hazards of Hospitalization [PDF]

Annals of Internal Medicine, 1964
The occurrence of hospital-induced complications on a university medical service was documented in the prospective investigation of over 1000 patients. The reported episodes were the untoward consequences of acceptable medical care in diagnosis and therapy. During the 8-month study, 240 episodes occurred in 198 patients.
openaire   +2 more sources