Results 81 to 90 of about 12,596,471 (331)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Conferencias anatomoclínicas: caso no. veintidos

open access: yesRevista de la Facultad de Medicina, 1955
E. A. v de C. 52 años. Ciudad de origen: Girardot. Ciudad de procedencia: Bogotá. Servicio del Profesor Guerrero Izquierdo. NOTA CLINICA: La enferma ingresa al Servicio de Urgencia el 13 de mayo de 1952 a las 5 :30 p. m.
San Juan de Dios Hospital
doaj  

Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025

open access: yesEurosurveillance
We measured effectiveness of nirsevimab against laboratory-confirmed respiratory syncytial virus (RSV) infection in a test-negative case-control study among children aged 
VEBIS hospital network RSV IE group
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Conferencias anatomoclínicas: caso no. diez y ocho

open access: yesRevista de la Facultad de Medicina, 1955
L. M. B. 16 años. Ciudad de Origen y Procedencia: Susa. Servicio del Prof. Manuel José Luque. NOTA CLINICA: La enferma ingresa al Servicio de Clínica Quirúrgica el 18 de enero de 1952, por presentar un bocio.
San Juan de Dios Hospital
doaj  

An exploration of the experience of midwifery care by women asylum seekers and refugees [PDF]

open access: yes
Background: There were approximately 63,097 known asylum seekers in England in 2002 (Heath et aL 2003). Women asylum seekers may be more seriously affected by displacement than men, leading to increased isolation, poverty, hostility and racism (Burnett ...
Briscoe, Lesley   +2 more
core  

Barnes Hospital Bulletin [PDF]

open access: yes, 1969
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1028/thumbnail ...

core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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