Results 61 to 70 of about 439,843 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The epidemiology of bloodstream infection contributing to mortality: the difference between community-acquired, healthcare-associated, and hospital-acquired infections

BMC Infectious Diseases, 2022
Background The epidemiology of bloodstream infection (BSI) is well-established; however, little is known about the contribution of different pathogens to mortality.
Seok Jun Mun, Si-Ho Kim, Hyoung-Tae Kim, Chisook Moon, Yu Mi Wi   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Point-prevalence survey of hospital acquired infections in three acute care hospitals in Northern Nigeria

Antimicrobial Resistance and Infection Control, 2020
Background Effective infection prevention and control strategies require reliable data describing the epidemiology of hospital acquired infections (HAIs), and this is currently lacking in Nigeria.
Usman Abubakar
doaj   +1 more source

Staphylococcus aureus surgical site infection rates in 5 European countries

Antimicrobial Resistance and Infection Control, 2023
Objective To determine the overall and procedure-specific incidence of surgical site infections (SSI) caused by Staphylococcus aureus (S. aureus) as well as risk factors for such across all surgical disciplines in Europe.
Sibylle C. Mellinghoff, Caroline Bruns, Markus Albertsmeier, Juliane Ankert, Louis Bernard, Sofia Budin, Camille Bataille, Annika Y. Classen, Florian B. Cornely, Elodie Couvé-Deacon, Maria Fernandez Ferrer, Jesús Fortún, Alicia Galar, Eva Grill, Thomas Guimard, Jürgen A. Hampl, Sebastian Wingen-Heimann, Juan P. Horcajada, Felix Köhler, Carolin Koll, Joan Mollar, Patricia Muñoz, Mathias W. Pletz, Jule Rutz, Jon Salmanton-García, Harald Seifert, Ferdinand Serracino-Inglott, Alex Soriano, Jannik Stemler, Janne J. Vehreschild, Tim O. Vilz, Jan-Hendrik Naendrup, Oliver A. Cornely, Blasius J. Liss   +33 more
doaj   +1 more source

Perioperative infection prophylaxis and risk factor impact in colon surgery [PDF]

, 2000
Background: A prospective observational study was undertaken in 2,481 patients undergoing elective colon resection in 114 German centers to identify optimal drug and dosing modalities and risk factors for postoperative infection.
Rau, H. G., Zimmermann, A., Lachmann, A., Kohler, L., Mittelkotter, U., Kullmann, K. H.   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pre-admission statin use and in-hospital severity of 2009 pandemic influenza A(H1N1) disease [PDF]

, 2011
In this group of patients hospitalized with pandemic influenza, a significant beneficial effect of pre-admission statin use on the in-hospital course of illness was not identified.
Brett, Stephen J., Semple, Malcolm G., Openshaw, Peter J. M., Semple, MG, Lim, Wei Shen, Bruce L Taylor, Puja Myles, Read, Robert C., Read, RC, McMenamin, J, Joanne E Enstone, Enstone, JE, McMenamin, Jim, Bruce L. Taylor, Nicholson, KG, Joanne E. Enstone, Jonathan S. Nguyen-Van-Tam, Myles, P, Malcolm G. Semple, Malcolm G Semple, Jim McMenamin, Lim, WS, Taylor, BL, Bannister, Barbara, Nguyen-Van-Tam, Jonathan S., Stephen J Brett, Peter J M Openshaw, Stephen J. Brett, Barbara Bannister, Jonathan S Nguyen-Van-Tam, Brett, SJ, Peter J. M. Openshaw, Karl G. Nicholson, Influenza Clinical Information Network (FLU-CIN), Nguyen-Van-Tam, JS, Taylor, Bruce L., Robert C. Read, Karl G Nicholson, Wei Shen Lim, null null, Enstone, Joanne E., Nicholson, Karl G., Openshaw, PJM, Robert C Read, Myles, Puja, Bannister, B   +45 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source