Results 61 to 70 of about 131,343 (255)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

THE ROLE OF PARTICIPATIVE MANAGEMENT (SUGGESTION SYSTEM) IN SHAHID FAYAZBAKHSH HOSPITAL EFFECTIVENESS AND EFFICIENCY

Journal of Research in Medical Sciences, 2003
Introduction: The undesirable use of available resources, shortage of resources, and increasing expenses of health care services, demonstrate the need for performing studies on the productivity of health care organizations and implementing the new ...
A.M MOSADEGH RAD
doaj  

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Inequality Assessment of Hospital Resources Distribution in West Azarbaijan Province Using Economic Indicators, Before-After Health System Reform plan

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2019
Background:  Equity in access to health care services is one of the main goals of health systems, so that inequality in the geographical distribution of health resources will make it difficult for individuals to access the health care facilities.
Soraya Golparipour, Bahram Nabilou, Hasan Yusefzadeh   +2 more
doaj  

Demographic and socio-economic factors affecting bed net ownership, usage, and malaria transmission among adult patients seeking healthcare in two Ghanaian urban cities

BMC Public Health
Background The most cost-effective malaria prevention and control strategy is the use of a bed net. However, several factors affect the ownership and usage of bed nets among the adult population.
Ellis Kobina Paintsil, Enoch Boadi, Anthony Dwamena, Bless Hayford Addo, Agyei Kumi, Kwasi Obiri-Danso, Linda Aurelia Ofori   +6 more
doaj   +1 more source

Paediatric bed capacity in Swiss hospitals: a comprehensive analysis

Swiss Medical Weekly
BACKGROUND: Switzerland’s decentralised healthcare system delegates responsibility for paediatric hospital infrastructure to individual cantons. To date, official statistics on the number and types of paediatric hospital beds are lacking.
Juliane Wurm, Christoph Berger, Vera Bernet, Simon Fluri, Magali Gauthey, Peter Gessler, Matthias V. Kopp, Juan Llor, Vincent Muehlethaler, Klara Posfay-Barbe, Guido F. Laube, Roger P. Lauener, Bjarte Rogdo, Rotraud K. Saurenmann, Giacomo D. Simonetti, Fabian Spigariol, Maren Tomaske, Rodo O. von Vigier, Abdelaziz Zemmouri, Petra Zimmermann, Urs Zimmermann, Henrik Koehler, Nicole Ritz   +22 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Developing a Quick Isolation Bed Inquiry System During the COVID-19 Outbreak: User-Centered Design Approach Based on the Toyota Production System

JMIR Formative Research
BackgroundDuring the COVID-19 outbreak in May 2021, our hospital—designated as a specialized facility for severely infected patients—faced critical staff and resource shortages.
Chien-Chung Lin, Jian-Hong Shen, Shan-Li Chang, Tai-Chih Kuo, Hui-Ling Huang, Cheng-Yi Peter Lin, Hung-Meng Huang   +6 more
doaj   +1 more source

Association between value-based purchasing score and hospital characteristics

BMC Health Services Research, 2012
Background Medicare hospital Value-based purchasing (VBP) program that links Medicare payments to quality of care will become effective from 2013. It is unclear whether specific hospital characteristics are associated with a hospital’s VBP score, and ...
Borah Bijan J, Rock Michael G, Wood Douglas L, Roellinger Daniel L, Johnson Matthew G, Naessens James M   +5 more
doaj   +1 more source