Results 91 to 100 of about 69,061 (248)

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Validation of The Hospital Episode Statistics Outpatient Dataset in England [PDF]

Value in Health, 2014
Thorn, J.C., Turner, E., Hounsome, L., Walsh, E., Down, L., Donovan, J., Verne, J., Neal, D., Hamdy, F., Martin, R.M., Noble, S.   +10 more
openaire   +3 more sources

Measuring multimorbidity in hospitalised patients using linked hospital episode data: comparison of two measures

International Journal of Population Data Science, 2019
Introduction Multimorbidity is a complex and growing health challenge. There is no accepted “gold standard” multimorbidity measure for hospital resource planning, and few studies have compared measures in hospitalised patients.
Lynn Robertson, Dolapo Ayansina, Marjorie Johnston, Angharad Marks, Corri Black   +4 more
doaj   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Spanish Hospital Cost Network Database: building a national benchmark from cost accounting practices

BMC Health Services Research
Background Crucial input for a wide range of healthcare management decisions is cost information: pricing services, benchmarking etc., as well as the economic evaluation of health technologies and policies all require accurate cost data and exactly where
Marc Carreras, Elisabet Buj-Gómez, Rocio Guerrero-Salinas, Mónica Núñez-García, Pere Oliveras-Alsina, Judit Pons-Cuni, Francesc Cots   +6 more
doaj   +1 more source

Linking the Diagnostic Imaging Dataset (DID) to Hospital Episode Statistics (HES) – improving and understanding the diagnosis of lung cancer

International Journal of Population Data Science, 2017
Objectives To link the Diagnostic Imaging Dataset (DID) to Hospital Episode Statistics (HES) to explore the association between patient imaging and hospital based care and outcomes for cancer patients in English NHS hospitals. This is the first time this
David Kennedy, Abigail Bentley, Erika Denton, Ella Ohuma, Nick Ormison-Smith, Sheila Dixon   +5 more
doaj   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Ethnicity and the surgical management of early invasive breast cancer in over 164 000 women

BJS (British Journal of Surgery), EarlyView., 2020
This large national study examined in detail the patterns in surgical management of early breast cancer in women of different ethnicities. Allowing for different patterns of age and stage at presentation, the surgical management of early breast cancer was similar in all women, regardless of ethnicity. All treated the same Background Limited information
T. Gathani, K. Chiuri, J. Broggio, G. Reeves, I. Barnes   +4 more
wiley   +1 more source

Under-recording of hospital bleeding events in UK primary care: a linked Clinical Practice Research Datalink and Hospital Episode Statistics study

Clinical Epidemiology, 2018
Laura McDonald,1,* Cormac J Sammon,2,* Mihail Samnaliev,2 Sreeram Ramagopalan1 1Centre for Observational Research and Data Sciences, Bristol-Myers Squibb, Uxbridge, UK; 2PHMR, Berkeley Works, London, UK *These authors contributed equally to this work ...
McDonald L, Sammon CJ, Samnaliev M, Ramagopalan S   +3 more
doaj