CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou +5 more
wiley +1 more source
Rebuilding Gaza's health system: A qualitative study of healthcare workers' experiences and lessons learned from responding to mass casualty incidents (2018-2021). [PDF]
Ismail A +4 more
europepmc +1 more source
CONTRIBUTION OF HOSPITALS TO NORTH DAKOTA'S ECONOMY [PDF]
Community hospital administrators in North Dakota were surveyed to determine the amount and type of expenditures made to North Dakota entities in 1997. Estimates of net revenues retained within the state were also solicited. Forty-two of the 44 community
Bangsund, Dean A., Leistritz, F. Larry
core +1 more source
IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang +18 more
wiley +1 more source
Comparative Cost Analysis of Ambulance Utilization: Advanced Life Support (ALS) vs Basic Life Support (BLS) at King Abdulaziz Medical City, Riyadh. [PDF]
Alabdali A, Alharkan M.
europepmc +1 more source
Health Basket and Health Block Grants Guidelines for the Disbursement of Funds, Preparation of Comprehensive Council Health Plans, Financial and Technical Reports and Rehabilitation of PHC Facilities by Councils [PDF]
Ministry of Health and Social Welfare, (MoHSW) +1 more
core
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche +21 more
wiley +1 more source
Overview and Preliminary Outcomes of a Children's Hospital Sponsored, Training Program Affiliated, School Based Dental Clinic. [PDF]
Hammersmith KJ +3 more
europepmc +1 more source

