Results 191 to 200 of about 44,349 (245)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Collaboration Between the Government and Healthcare Professional Organizations for the Implementation of Geriatric Emergency Departments in Taiwan. [PDF]

J Acute Med
Lee CH, Tan TH, Yang CJ, Ng CJ, Wu CY, Wu CC.   +5 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Facilitators and barriers of general health service readiness in the primary level public health facilities of Baitadi, Nepal: A qualitative study. [PDF]

PLOS Glob Public Health
Bist A, Arjyal A, Subedi M.
europepmc   +1 more source

Breaking ground: insights from a WHO-approved surgical mission amid Sudan's healthcare collapse. [PDF]

Front Public Health
Irfan B, Ali S, Ardah R, Jaffery Z, Ahmed A, Othman N, Ali A, Ali SIQ, Burney M.   +8 more
europepmc   +1 more source

Procedural Case: Neonatal Lumbar Puncture. [PDF]

J Educ Teach Emerg Med
Lei C, Cohen S, Melendez A, Wallace N, Moadel T, Beattie L, Chen T, Fernandez D, Stapleton S, Aldalati A.   +9 more
europepmc   +1 more source

Health system barriers and facilitators influencing the uptake of cervical cancer screening among women in sub-Saharan Africa: systematic review and meta-synthesis. [PDF]

BMC Health Serv Res
Daniels-Donkor SS, Marryat L.
europepmc   +1 more source

Redesign of Bedside Supply Carts to Improve Emergency Department Workflows: Mixed Methods Participatory Design.

JMIR Hum Factors
Hefter K, Dreibelbis S, Haupt T, McIver A, Wang A, Dwight J, Nwodim O, Ray N.   +7 more
europepmc   +1 more source

Towards dignified healthcare: Patients' understanding and experiences of respectful and disrespectful care in healthcare facilities in Ghana. [PDF]

PLOS Glob Public Health
Abaidoo B, Essuman VA, Addo AK, Getahun M, Amoh G, Aborigo RA, Ali M, Essuman A, Odiase O, Yawson AE, Afulani P.   +10 more
europepmc   +1 more source

Abortion in conflict zones: moral responsibilities of humanitarian agencies in providing safe abortion care. [PDF]

Front Reprod Health
Anokwuru CC, Ekwebene OC, Nwuzoh MI, Edeh GC, Nwalieji CA, Udokang EI, Obi CG, Eneh S.   +7 more
europepmc   +1 more source