Results 61 to 70 of about 947,668 (293)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Internações no sistema de serviços hospitalares, SUS e não SUS: Brasil, 2006 Hospital admissions in the hospital health care system, SUS and non-SUS: Brazil, 2006

open access: yesRevista Brasileira de Epidemiologia, 2011
O objetivo deste estudo foi descrever as admissões, SUS e não SUS, no Sistema de Serviços Hospitalares no Brasil no ano de 2006, adotando o indivíduo internado como unidade de análise. As fontes dos dados foram o Sistema de Informação Hospitalar (SIH/SUS)
Marizélia Leão Moreira   +1 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Information security risk management for computerized health information systems in hospitals: a case study of Iran

open access: yesRisk Management and Healthcare Policy, 2016
Javad Zarei,1 Farahnaz Sadoughi2 1Health Information Management, Health Management and Economics Research Center, School of Health Management and Information Science, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran, 2Health ...
Zarei J, Sadoughi F
doaj  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

وضعیت امنیت اطلاعات در سیستم‌های اطلاعات بیمارستانی

open access: yesمدیریت اطلاعات سلامت, 2013
مقدمه: امروزه، با ظهور پرونده‌ی الکترونیکی بیمار، نیاز به تبادل اطلاعات افزایش یافته و در نتیجه امنیت و محرمانگی در سیستم‌های اطلاعاتی باید بیش‌تر مورد توجه قرار گیرد.
Esmaeil Mehraeen   +2 more
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

The Relationship between Hospital Information System and Psychological Empowerment of Hospital Employees

open access: yesمدیریت اطلاعات سلامت, 2016
Introduction: Employee empowerment is a process that requires appropriate conditions in the organization. The application of information systems in the health sector as a pragmatic approach and critical element in empowering employees provides the ...
Masoumeh Rahimipour   +2 more
doaj  

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