Results 161 to 170 of about 15,897,913 (288)

Cell‐Free DNA as a Biomarker of Cell Death and Treatment Response for On‐Chip Three‐Dimensional Tumor Models

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents quantifying cell‐free DNA (cfDNA) as a non‐disruptive and rapidly quantifiable method for assessing cell death for on‐chip 3D sarcoma tumor models. On‐chip cfDNA release reflects tumor burden, extent of cell death, and survival of in vitro and ex vivo 3D models, providing valuable insight into the temporal response of tumor models ...
Maryam Ziaee   +7 more
wiley   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu   +13 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

open access: yesAdvanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng   +4 more
wiley   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

open access: yesAdvanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick   +4 more
wiley   +1 more source

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

open access: yesAdvanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz   +9 more
wiley   +1 more source

Bioinspired Adaptive Artificial Cilia With Tunable Sensitivity and Dynamic Range for Airflow Monitoring in the Central Airway

open access: yesAdvanced Materials Technologies, EarlyView.
A magnetically reconfigurable airflow sensor integrated with an airway stent enables tunable sensitivity and dynamic sensing range. Airflow‐induced cantilever deformation generates resistance changes, while an external magnetic field modulates sensor stiffness, enhancing sensitivity at low airflow velocities and extending the sensing range at higher ...
Darren Wang   +10 more
wiley   +1 more source

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