Results 191 to 200 of about 15,897,913 (288)

Mapping Randomized Controlled Trials of Family- and Community-Centered Healthcare Interventions for Pediatric Asthma, Type 1 Diabetes, or Juvenile Idiopathic Arthritis-A Scoping Review. [PDF]

Children (Basel)
Solgaard Nielsen S, Bricca A, Orologas S, Malby Schoos AM, Bohr AH, Østergaard KL, Mondahl J, Gram SA, Grabowski D, Bilgin FD, Hoppe MSO, Rasmussen TP, Simonÿ C, Luijk A, Remmen LN, Hallas H, Mittet L, Jensen MT, Christensen JR.   +18 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Access, equity, and innovation in the management of the open abdomen: the lack of proper treatment and the impact in low-income populations. [PDF]

Trauma Surg Acute Care Open
Fontenelle Ribeiro MA.
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Making Home-Based End-of-Life Care a Realistic Choice: A Narrative Review of Linkages Between Community Care and Specialized Hospice Institutions in South Korea. [PDF]

J Hosp Palliat Care
Kwon SH.
europepmc   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

How Do Nurses Navigate the Challenges of Risk Management? Results from a Cross-Sectional Survey in Southern Italy. [PDF]

Healthcare (Basel)
Ponticelli D, Del Giudice C, Rozza D, Maglia E, Losa L, Antonazzo IC, Amigoni C, D'Orso MI, Zampella A, Tartaglia D, Fede MN, Gallucci F, Magliuolo R, Arcari A, Rainone A, Geraci G, Mottola G, Ausili D, Mantovani LG, Ferrara P.   +19 more
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

A full review of online OPAT educational resources for patients and healthcare professionals in the grey literature revealing resource gaps. [PDF]

JAC Antimicrob Resist
Watson C, Spencer-Jones J, Heard K, Jenkins A, Gauthier TP, Rogers BA, Nor ANM, Sime FB, Gilchrist M.   +8 more
europepmc   +1 more source