Results 91 to 100 of about 12,269,852 (245)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Introducing Unit Dose Dispensing in a University Hospital – Effects on Medication Safety and Dispensing Time

Risk Management and Healthcare Policy
Hanne Katriina Ahtiainen,1,2 Carita Lindén-Lahti,1,2 Susanna Heininen,1 Anna-Riia Holmström,1 Lotta Schepel2,3 1Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2HUS Pharmacy, Helsinki University Hospital, Helsinki, Finland; 3Quality and ...
Ahtiainen HK, Lindén-Lahti C, Heininen S, Holmström AR, Schepel L   +4 more
doaj  

Impact of Artificial Intelligence on the Future of Clinical Pharmacy and Hospital Settings

Journal of Research in Pharmacy Practice
This review aimed to comprehensively evaluate the impact of artificial intelligence (AI) on the future of clinical pharmacy practice and hospital settings.
Hadi Hamishehkar, Mehrdad Shahidi
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Evaluation of factors contributing to medication errors among Nurses working at Mbagathi district hospital. [PDF]

, 2015
Kenya healthcare policies provide that patient's dignity be observed by ensuring medical safety practices are observed. In this case, medication errors are a concern for both healthcare professionals as well as patients. The main aim of this study was to
Koech, Jane Jebet
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

The rate and nature of medication errors among elderly upon admission to hospital after implementation of clinical pharmacist-led medication reconciliation

, 2014
Objectives To determine the frequency and nature of erroneous transfer of medication information (medication errors) upon admission to hospital and to study the effect of medication reconciliation.
Eriksson, Tommy,, Lund University., Waleij, Leila,, Midlöv, Patrik,, Höglund, Peter,   +4 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Wild medicine - exploring medication management challenges in transition and interaction across actors and health sectors related to older adults receiving polypharmacy: a qualitative study

BMC Geriatrics
Background Adverse drug events represent the largest category of incidents health professionals report to regional authorities in Denmark and remain a significant challenge globally.
Gitte Wind, Karen-Marie Olesen, Janne Friis Andersen, Line Hillersdal   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source