Results 281 to 290 of about 1,388,861 (350)

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Diurnal variation of the distance between cranium and the third lumbar vertebra and its implications for craniospinal irradiation. [PDF]

Phys Imaging Radiat Oncol
Heikkilä A, Rossi M, Vanhanen A, Koivumäki T, Postema M, Boman E.   +5 more
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

The compliance of the training program for hospital accreditation surveyors in Iran with the international requirements: a mixed-methods study. [PDF]

BMC Health Serv Res
Poursaki T, Shams L, Maher A, Gharibi F.
europepmc   +1 more source

AI integration in energy management: enhancing efficiency in Italian hospitals. [PDF]

Health Econ Rev
Pariso P, Picariello M, Marino A.
europepmc   +1 more source

New imaging findings of tumor invasion into brain tissue: "Peritumoral Hyperintense Enhancement Sign". [PDF]

Front Hum Neurosci
Mao X, Li J, Zheng X, Wang Y, Gao J, Fu C, Li X, Liang M, Wang X, Qiu T, Du H, Xue C, Liu Y.   +12 more
europepmc   +1 more source

Motion control and singular perturbation algorithms for lower limb rehabilitation robots. [PDF]

Front Neurorobot
Xie Y, Wang A, Zhao X, Jiang Y, Wu Y, Yu H.   +5 more
europepmc   +1 more source

Relationships between internal facilitation processes and implementation outcomes among hospitals participating in a quality improvement collaborative to reduce cesarean births: a mixed-methods embedded case study. [PDF]

Implement Sci Commun
Callaghan-Koru JA, Breman RB, DiPietro B, Henderson L, Curran G.   +4 more
europepmc   +1 more source

Editorial: The digital transformation of dental and maxillofacial practice towards preventive, personalised, and precision medicine. [PDF]

Front Oral Health
Lo Giudice G, Boschetti CE, Nastro Siniscalchi E.   +2 more
europepmc   +1 more source