Results 91 to 100 of about 1,038,592 (309)

Fifteenth annual report of the Board of Managers of West Philadelphia Hospital for Women

, 1905
Annual reports of the board of managers of West Philadelphia Hospital for Women documenting the hospital activity, including lists of committee reports, statistics on patients treated, information on nursing training, and donor lists.

core  

SHP2 in TAMs promoted the survival of gastric adenocarcinoma via suppressing the P38/ERK1/2/SP1/BRD4/STING induced inflammation and ROS

Frontiers in Medicine
BackgroundIt is well established that tumor-associated macrophages (TAMs) are crucial to the development of tumors. Here, we looked into how SHP2 and M2/M1 macrophages affected gastric cancer.MethodsBulk RNA-seq analysis was conducted using the GSE118916
Jing Bai, Hui Ren, Yachen Zhang, Xiao Li
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Seventeenth annual report of the Board of Managers of West Philadelphia Hospital for Women

, 1907
Annual reports of the board of managers of West Philadelphia Hospital for Women documenting the hospital activity, including lists of committee reports, statistics on patients treated, information on nursing training, and donor lists.

core  

Exploring the association between brominated flame retardant exposure and the risk of rheumatoid arthritis: A comprehensive analysis

Ecotoxicology and Environmental Safety
Brominated flame retardants (BFRs), widely used for their flame-retardant properties, have raised global health concerns. Given the limited evidence linking BFRs to rheumatoid arthritis (RA), we investigated the association between BFR exposure and RA ...
Xiaobing Feng, Bingrong Tang, Han Xia, Yue Zhang, Ling Zheng, Yuji Wang, Min Wang, Ruyi Liang, Chunxiang Yan   +8 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Twenty-Eighth Annual Report of the Board of Managers of the West Philadelphia Hospital for Women

, 1918
Annual reports of the board of managers of West Philadelphia Hospital for Women documenting the hospital activity, including lists of committee reports, statistics on patients treated, information on nursing training, and donor lists.

core  

Identifying pathways to cardiovascular mortality by causal graphical models and mediation analysis among hypertensive patients: insights from a prospective study

Journal of Translational Medicine
Background Many biochemical markers are involved in cardiovascular (CV) prognosis in the hypertensive population, but most findings are derived from a single-exposure setting, and their interaction and potential pathways remain scarce.
Simiao Tian, Zhen Li, Yanhong Bi, Xiaoyu Che, Ao Feng, Yiou Wang   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source