Results 161 to 170 of about 88,107,133 (294)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

Hospital Ward photo

open access: yes
Black and white photo of some beds in an empty ward in Modbury ...
Modbury Hospital
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

open access: yesAdvanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li   +19 more
wiley   +1 more source

Informal Caregivers in Transitional Hospital-to-Home Care for Older People: Addressing Gaps in Pre-Discharge Collaboration for Enhanced Patient Outcomes

open access: yesPatient Preference and Adherence
Filipa Pereira,1,2 Catherine Bolduc,2 Pauline Melly,1 Virginie Renggli2 1School of Health Sciences, HES-SO Valais-Wallis, Sion, Switzerland; 2Valais Romand Hospital Centre, Sion, SwitzerlandCorrespondence: Filipa Pereira, School of Health Sciences, HES ...
Pereira F, Bolduc C, Melly P, Renggli V
doaj  

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

open access: yesAdvanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao   +15 more
wiley   +1 more source

An Innovative Transitional Care Unit for Hospital to Home Transition of Children With Medical Complexity: A Qualitative Study of Parents' Experiences. [PDF]

open access: yesChild Care Health Dev
Haspels HN   +6 more
europepmc   +1 more source

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