Results 141 to 150 of about 5,109,898 (358)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Modelo de organizacion de una unidad de emergencia hospitalaria en funcion de la demanda observada [PDF]
, 1997 145 p.Se propone una metodología general que permite, adecuando la oferta de horas profesionales existente en las Unidades de Emergencia de los hospitales públicos a la demanda observada, una organización más eficiente de ellas.
Baechler Rojas, Roberto (Prof. Guía) +2 more
core
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients
npj Breast CancerEarly breast cancer patients often experience relapse due to residual disease after treatment. Liquid biopsy is a methodology capable of detecting tumor components in blood, but low concentrations at early stages pose challenges.
Alfonso Alba-Bernal +23 more
doaj +1 more source
La introducción del hospital contemporáneo en España : la quiebra del modelo originario de organización de la Casa de la Salud Valdecilla de Santander [PDF]
, 1987 La Casa de ~alud\laldecillad e Santander nació en 1928 con clara y firme voluntad de conectar, tanto desde el punto de vista organizativo como desde el funcional, con los más innovadores hospitales europeos y norteamericanos de la época, rompiendo ...
Arrizabalaga, Jon +2 more
core +4 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source