Results 181 to 190 of about 270,120 (271)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Epidemiology of the COVID-19 pneumonia in a group of hospitals from Madrid-Spain during the full period of the State of Alarm HM cohort. [PDF]

Rev Esp Quimioter
Barberán J, Ramos M, Villanueva J, Villares P, Villareal M, Vivas M, Orche S, Tejera-Gonzalez M, Menéndez JM, Hinojosa LT, Almirall C, Antolin L, Martinez L, Mendoza S, Pelaez A, Segarra-Cañamares M, Guerrero JE, Pelaez J, Cardinal-Fernández P.   +18 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

[Pathological anatomy and its importance in the hospital setting]. [PDF]

Rev Med Inst Mex Seguro Soc
Dragustinovis-Valdez IY, Naranjo-Baltazar P.   +1 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

[Alzheimer's and Its Diagnosis: Are We Prepared to Accompany Our Patients? Shared Care Planning as a Relational Framework]. [PDF]

Rev Neurol
Eimil-Ortiz M, Alcántara-Miranda P, Martínez-Morante S.   +2 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

[Strategies and Barriers to the Implementation of Continuing Education in Sentinel Hospitals for the Surveillance of COVID-19 Vaccine Safety in Honduras, 2022-2023Formação continuada: estratégias e barreiras de implementação em hospitais sentinela para a vigilância da segurança das vacinas contra a COVID-19 em Honduras, 2022-2023]. [PDF]

Rev Panam Salud Publica
Zúniga C, Cárcamo E, Romualdo-Tello NM, Solarte Agredo IN, Álvarez V, Moya I, Galeas J, Burgos N, Raudales A, Zapata L, Soto S, Gamero M.   +11 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

[May you benefit from what you see: A humanistic reflection on the palliative gaze]. [PDF]

An Sist Sanit Navar
Torres-Tenor JL.
europepmc   +1 more source